Stefanie D. Krämer, PD Dr.

Research Interests

Kinetics from the molecular scale ...

• permeation across lipid membranes
• protein-mediated transport, e.g., P-glycoprotein
• enzyme-catalyzed reactions, e.g., alpha-cleavage of APP

... to the region of interest scale

• PET (Positron Emission Tomography) kinetics

... to the macroscopic scale

• Pharmacokinetics

PET (Positron Emission Tomography)

see Radiopharmaceutical Sciences >>

• In vitro / preclinical characterization of candidate PET probes
• Evaluation of targets for PET imaging
• PET imaging

Education & Positions held

2009-present
Research associate in Radiopharmaceutical Sciences, head of pharmacology division
Institute of Pharmaceutical Sciences, ETH Zurich, Switzerland

2000 / 2008 - present
Research associate / head of Biopharmacy division
Institute of Pharmaceutical Sciences, ETH Zurich, Switzerland

1998-2000
Postdoctoral fellow of the Wellcome Trust (UK) in blood-brain barrier research with Dr. David Begley and Prof. N. Joan Abbott at the School of Biomedical Sciences, King’s College, London, UK
Research topic: influence of glioma cells on the lipid and lipid fatty acid patterns of in vitro BBB models

1997-1998
Postdoctoral fellow with a grant from ELF Aquitaine at Sanofi Research, Montpellier (F), with Dr. Jean-Claude Gautier and Dr. Philippe Saudemon
Research topic: absorption prediction from physicochemical parameters

1996-1997
Postdoctoral fellow and teaching assistant in Biopharmacy with Prof. H. Wunderli-Allenspach at the Institute of Pharmaceutical Research, ETH, Zürich, Switzerland
Research topic: drug-lipid membrane interactions

1996
Ph.D. in natural sciences
Swiss Federal Institute of Technology, Zürich, Switzerland
Ph.D. Thesis: "pH-dependent partition behavior of 3H-(RS)-propranolol in various liposome/buffer systems"
Thesis committee: H. Wunderli-Allenspach, A. Fahr, G. Folkers

1990-1996
Graduate studies and teaching assistant in Biopharmacy with Prof. H. Wunderli-Allenspach, Institute of Pharmaceutical Sciences, ETH, Zürich, Switzerland

1989-1990
Working as pharmacist in a public pharmacy in Zürich

1989
Diploma as eidg. dipl. pharmacist

1984-1989
Undergraduate studies in Pharmaceutical Sciences at ETH, Zürich, Switzerland