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Tight Junction proteins as targets for permeation enhancemen
The extracellular loops of TJ proteins
have been reported to be involved in the regulation of the tightness of
the TJ seal. We use the extracellular loops of TJ-proteins as targets
to search for possible ways to reversibly loosen the TJ intercellular
seal in order to enhance the paracellular flux of low molecular weight
compounds or macromolecules. An easily accessible model system is being
developed that allows the systematic screening of low molecular weight
compound chemical libraries, as well as peptide and antibody libraries.
The controlled reversible loosening of TJs without affecting
intracellular calcium levels and signaling pathways could offer a new
avenue for the enhancement of in vivo barrier passage of otherwise
non-permeating therapeutic agents.
ETH Research Database: id 13639
Contacts: Prof.
Dr. Heidi Wunderli-Allenspach, Dr.
Stefanie Krämer
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