Rodrigues, Tiago, Dr.

ETH Zürich Dr. Tiago Rodrigues Inst. f. Pharmazeutische Wiss. HCI G 492.5 Wolfgang-Pauli-Str. 10 8093 Zuerich Phone: +41 44 633 91 13 E-Mail:

Areas of interest

• Medicinal Chemistry
• Molecular modeling
• Infectious Diseases

Publications

• F. P. da Cruz, C. Martin, K. Buchholz, M. J. Lafuente-Monasterio, T. Rodrigues, B. Sönnichsen, R. Moreira, F.-J. Gamo, M. Marti, M. M. Mota, M. Hannus, M. Prudêncio; High-throughput drug screen targeted at Plasmodium liver stages identifies a potent multi-stage anti-malarial drug; J Infect Dis, 2012, 205, 1278-1286.
• T. Rodrigues, M. Prudêncio, R. Moreira, M. M. Mota, F. Lopes; Targeting the Liver Stage of Malaria Parasites: A Yet Unmet Goal, J Med Chem 2012, 55, 995-1012
• A. Klenner, V. Hähnke, T. Geppert, P. Schneider, H. Zettl, S. Haller, T. Rodrigues, F. Reisen, B. Hoy, A. M. Schaible, O. Werz, S. Wessler, G. Schneider; From virtual screening to bioactive compounds by visualizing and clustering of chemical space, Mol Inf 2012, 31, 21-26
• T. Rodrigues, F. Lopes, R. Moreira; Microwave-assisted Wittig reaction of semistabilized nitro-substituted benzyltriphenyl- phosphorous ylides with aldehydes in phase-transfer conditions, Synth Commun 2012, 42, 747-755
• T. Rodrigues, J. Gut, P. J. Rosenthal, P. M. O’Neill, G. A. Biagini, R. Moreira, F. Lopes, D. J. V. A. dos Santos, R. C. Guedes; Identification of new antimalarial leads by use of virtual screening against cytochrome bc1, Bioorg Med Chem 2011, 19, 6302-6308
• T. Rodrigues, R. Moreira, F. Lopes; New hope in the fight against malaria?, Future Med Chem 2011, 3, 1-3. (Invited Editorial)
• T. Rodrigues, D. J. V. A. dos Santos, R. Moreira, F. Lopes, R. C. Guedes; A quantum mechanical study of novel potential inhibitors of cytochrome bc1 as antimalarial compounds, Int J Quantum Chem 2011, 111, 1196-1207
• T. Rodrigues, F. Lopes, R. Moreira; Inhibitors of the Mitochondrial Electron Transport Chain and de novo Pyrimidine Biosynthesis as Antimalarials: The Present Status, Curr Med Chem 2010, 17, 929-956
• T. Rodrigues, R. C. Guedes, D. J. V. A. dos Santos, M. Carrasco, J. Gut, P. J. Rosenthal, R. Moreira, F. Lopes; Design, synthesis and Structure Activity-Relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials, Bioorg Med Chem Lett 2009, 19, 3476-3480
• T. Rodrigues, R. Moreira, B. Dacunha-Marinho, F. Lopes; Bis{(E)-3-[(diethylmethylammonio)methyl]-N-[3-(N,N-dimethylsulfamoyl)-1-methylpyridin-4-ylidene]-4-methoxyanilinium} tetraiodide pentahydrate; Acta Cryst E. 2009, E65, o283-o284
• T. Rodrigues, R. Moreira, R. C. Guedes, J. Iley, F. Lopes; Unanticipated Acyloxymethylation of Sumatriptan Indole Nitrogen Atom and its Implications in Prodrug Design; Arch Pharm Chem Life Sci 2008, 341, 344-350