Publications

2011

Vigl, B., Aebischer, D., Nitschké, M., Iolyeva, M., Röthlin, T., Antsiferova, O.  and Halin, C. (2011) Tissue inflammation modulates gene expression of lymphatic endothelial cells and dendritic cell migration in a stimulus-dependent manner. Blood, 118(1):205-15

2010

Mumprecht V, Honer M, Vigl B, Proulx ST, Trachsel E, Kaspar M, Banziger-Tobler NE, Schibli R, Neri D, Detmar M. (2010) In vivo imaging of inflammation- and tumor-induced lymph node lymphangiogenesis by immuno-positron emission tomography. Cancer Res. 70: 8842-51.

Jurisic G, Iolyeva M, Proulx ST, Halin C, Detmar M. (2010) Thymus cell antigen 1 (Thy1, CD90) is expressed by lymphatic vessels and mediates cell adhesion to lymphatic endothelium. Exp Cell Res. 316: 2982-92

Kumar V, Scandella E, Danuser R, Onder L, Nitschké M, Fukui Y, Halin C, Ludewig B, Stein JV. (2010) Global lymphoid tissue remodeling during a viral infection is orchestrated by a B cell-lymphotoxin-dependent pathway. Blood, 115: 4725-33

2009

Vigl B., Zgraggen C., Rehman N., Banziger-Tobler NE., Detmar M., Halin C. (2009) Coxsackie-and adenovirus receptor (CAR) is expressed in lymphatic vessels in human skin and affects lymphatic endothelial cell function in vitro. Exp Cell Res. 315: 336-47

2008

Tobler, N.E., Halin, C., Kajiya, K. and Detmar, M. (2008) Growth hormone promotes lymphangiogenesis. Am. J. Pathol. 173, 586-97

Halin C, Detmar M. (2008) Inflammation, angiogenesis and lymphangiogenesis. Methods Enzymol, 445: 1-25

Halin C., Fahrngruber H., Meingassner J.G., Bold G., Littlewood Evans A., Stuetz A., Detmar M. Inhibition of chronic and acute skin inflammation by treatment with a VEGF receptor tyrosine kinase inhibitor. Am. J. Pathol. 173: 265-77

2007

Zehnder-Fjällmann AH, Marty C., Halin C., Hohn A., Schibli R., Ballmer-Hofer K., Schwendener RA. (2007) Evaluation of anti-VEGFR-3 specific scFv antibodies as potential therapeutic and diagnostic tools for tumor lymph-angiogenesis. Oncol Rep. 18: 933-41.

Halin C., Tobler NE., Vigl B., Brown LF., Detmar M. (2007) VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes. Blood, 110: 3258-67

2006

Halin C., Detmar, M. An unexpected connection: lymph node lymphangiogenesis and dendritic cell migration. Immunity, 24, 129-31, 2006

2005

Halin, C., Mora, J.R., Sumen, C. and von Andrian U.H., In vivo imaging of lymphocyte trafficking. Annual Reviews of Cell and Developmental Biology, 21, 581-603, 2005.

Cavanagh, L.L., Bonasio, R., Mazo, I.B., Halin, C., Cheng, G., van der Velden, A.W.M., Cariappa, A., Chase, C., Russell, P., Starnbach, M.N., Pillai, S., Weninger, W. and von Andrian, U.H., Circulating dendritic cells home to the bone marrow and present antigen to resident T cells. Nature Immunology, 6, 1029-1037, 2005.

Halin, C., Scimone, M.L., Bonasio, R., Gauguet, J.M, Mempel, T.R., Quackenbush, E. Proia, R.L., Mandala, S. and von Andrian, U.H., The S1P-analog FTY720 differentially modulates T cell homing via HEV: T cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer’s patches. Blood, 106, 1314-1322, 2005.

2004

Matter, C.M., Schuler, P.K., Alessi, P., Meier, P., Ricci, R., Zhang., D., Halin. C., Castellani, P., Zardi, L., Hofer, C.K., Montani, M. and Neri, D., Molecular imaging of athersocleotic plaques using a human antibody against the extra-domain B of fibronectin. Circulation Research, 95, 1225-1233, 2004.

2003

Halin, C., Gafner, V., Villani, M.E., Borsi, L., Berndt, A., Kosmehl, H., Zardi, L. and Neri, D., Synergistic therapeutic effects of a tumor targeting antibody fragment, fused to interleukin-12 and to tumor necrosis factor alpha. Cancer Research, 63, 3202-3210, 2003

2002

Melkko, S., Halin, C., Borsi, L., Zardi, L. and Neri, D., An antibody-calmodulin fusion protein reveals a functional dependence between macromolecular isoelectric point and tumor targeting performance. Int. J. Radiat Oncol Biol Phys., 54, 1485-1490, 2002.

Halin, C., Niesner, U., Villani, M.-E., Zardi, L. and Neri, D., Tumor targeting properties of antibody-VEGF fusion proteins. International Journal of Cancer, 102, 109-116, 2002.

Niesner, U., Halin, C., Lozzi, L., Günthert, M., Neri, P., Wunderli-Allenspach, H., Zardi L., and Neri, D., Quantitation of the tumor targeting properties of antibody fragments conjugated to cell-permeating HIV-1 TAT peptides. Bioconjugate Chemistry, 13, 729-736, 2002.

Halin, C., Rondini, S., Nilsson, F., Berndt, A., Kosmehl, H.,Zardi, L. and Neri, D., Enhancement of the anti-tumor activity of interleukin-12 by targeted delivery to the neo-vasculature. Nature Biotechnology, 20, 264-269, 2002.

2001

Halin, C., Zardi, L. and Neri, D., Antibody-based Targeting of Angiogenesis. News in Physiological Sciences, 16(4), 191-194, 2001.

Halin, C. and Neri, D., Antibody-based Targeting of Angiogenesis. Critical Reviews in Therapeutic Drug Delivery Systems, 18(3), 299-339, 2001.

1999

Birchler, M., Neri, G., Tarli, L., Halin, C., Viti, F., Neri, D., Infrared photodetection for the in vivo localisation of phage-derived antibodies directed against angiogenic markers. Journal of Immunological Methods, 231(1-2), 239-48, 1999.

Dall'Acqua, W., Halin, C., Rodrigues, M.L. and Carter, P., Elastase substrate specificity tailored through substrate-assisted catalysis and phage display. Protein Engineering, 12(11), 981-7, 1999.

1997

Neri, D., Carnemolla, B., Nissim, A., Leprini, A., Querze, G., Balza, E., Pini, A., Tarli, L., Halin, C., Neri, P., Zardi, L. and Winter, G., Targeting by affinity-matured recombinant antibody fragments of an angiogenesis associated fibronectin isoform. Nature Biotechnology, 15(12), 1271-5, 1997.