1993-1999

Nucleoside- and Nucleotide Chemistry, Biochemistry, and Biophysical Characterization

• D. Fabbro, B. P. Monia, K.-H. Altmann, M. Müller, T. Geiger, “Inhibition of Tumor Growth by Antisense Oligonucleotides Targeting the Growth Related Protein Kinase c-raf”, in Methods in Molecular Medicine, Vol 35: Gene Therapy of Cancer: Methods and protocols W. Walter, U. Stein, Eds., Humana Press Inc., Totowa, NJ, 1999, pp. 167 - 188. (Review)
• P. von Matt, A. De Mesmaeker, U. Pieles, W. Zürcher, K.-H. Altmann. Tetrahedron Lett. 1999, 40, 2899-2902.
  “2-Deoxyribo-PNAs: A Structurally Novel Class of Polyamide Nucleic Acids with Good RNA and DNA binding affinity”.
• T. V. Maltseva, K.-H. Altmann, M. Egli, J. Chattopadhyaya. J. Biomol. Structure & Dynamics 1998, 16, 569-578.
• P. von Matt, R. Kesselring, K.-H. Altmann. Tetrahedron Lett. 1999, 40, 1873-1876.
  “An Expeditious Synthesis of 3’--Carboxymethyl-2’-O-Methyl Ribonucleosides”.
• A. Y. Denisov, E. V. Zamaratski, T. V. Maltseva, A. Sandström, S. Bekiroglu, K.-H. Altmann, M. Egli, J. Chattopadhyaya. J. Biomol. Structure & Dynamics 1998, 16, 547-568.
  “The Solution Conformation of a Carbocyclic Analog of the Dickerson-Drew Dodecamer: Comparison with its own X-ray Structure and that of the NMR Structure of the Native Counterpart”.
• K.-H. Altmann, D. Fabbro, T. Geiger, "Antisense and Anti-Gene Therapy in Oncology", in "Advances in DNA Sequence Specific Agents", G. B. Jones, Ed., JAI Pres, 1998, pp. 227 - 266. (Review)
• M. Egli, S. Portmann, F. Natt, P. Martin, K.-H. Altmann. Biochemistry 1998, 30, 10626-10634.
  "Correlating Structure and Stability of DNA Duplexes with Incorporated 2’-O-Modified RNA Analogues"
• S. M. Freier, K.-H. Altmann, Nucleic Acids Res. 1997, 25, 4429 - 4443.
  "The Ups and Downs of Nucleic Acid Duplex Stability" (Review).
• B. Cuenoud, F. Caset, D. Hüsken, F. Natt, R. M. Wolf, K.-H. Altmann, P. Martin, H. E. Moser, Angew. Chem. Int. Ed. 1998, 37, 1288 - 1291.
  “Dual Recognition of Double-Stranded DNA by 2'-Aminoethoxy-Modified Oligonucleotides”.
• M. Egli, S. Portmann, F. Natt, P. Martin, K.-H. Altmann. Biochemistry 1998, 30, 10626-10634.
  "Correlating Structure and Stability of DNA Duplexes with Incorporated 2’-O-Modified RNA Analogues"
• K.-H. Altmann, B. Cuenoud, P. von Matt, "Novel Chemistry", in Applied Antisense Oligonucleotide Technology, A. M. Krieg, C. A. Stein, Eds., Wiley, New York, 1998, pp. 73 -108. (Review)
• S. Portmann, K.-H. Altmann, N. Reynes, M. Egli, J. Am. Chem. Soc. 1997, 119, 2396 - 2403.
  " Crystal Structures of Oligodeoxyribonucleotides Containing 6'--Methyl and 6’--Hydroxy Carbocyclic Thymidines".
• K.-H. Altmann, C. Schmit Chiesi, C. Garcia-Echeverria, Bioorg. Med. Chem. Lett. 1997, 7, 1119 - 1122.
  "Polyamide Based Nucleic Acid Analogs ‑ Synthesis of -Amino Acids with Nucleic Acid Bases Bearing Side Chains".
• C. Garcia-Echeverria, C. Schmit Chiesi, D. Hüsken, K.-H. Altmann, Bioorg. Med. Chem. Lett. 1997, 7, 1123 - 1126.
  "Polyamide Based Nucleic Acid Analogs ‑ Synthesis of Oligomers and RNA-Binding Properties".
• G. D. Jones, K.-H. Altmann, D. Hüsken, R. T. Walker, Bioorg. Med. Chem. Lett. 1997, 7, 1275 - 1278.
  "Duplex- and Triplex-Forming Properties of 4’-Thio-Modified Oligodeoxynucleotides".
• P. von Matt, T. Lochmann, K.-H. Altmann, Bioorg. Med. Chem. Lett. 1997, 7, 1549 - 1552.
  "Replacement of the Phosphodiester Linkage in Oligonucleotides by Heterocycles: Synthesis of Thymidine Dinucleotide Analogs with Triazole Modified Backbones".
• P. von Matt, T. Lochmann, K.-H. Altmann, Bioorg. Med. Chem. Lett. 1997, 7, 1553 - 1556.
  "Replacement of the Phosphodiester Linkage in Oligonucleotides by Heterocycles: The Effect of Triazole- and Imidazole-Modified Backbones on DNA/RNA Duplex Stability".
• J. Ammenn, K.-H. Altmann, D. Bellus, Helv. Chim. Acta 1997, 80, 1589 - 1606.
  "Aza-Claisen Rearrangement: Synthesis of 5’-Branched 5’-Aminothymidines".
• K.-H. Altmann, P. Martin, N. M. Dean, B. P. Monia, Nucleosides & Nucleotides 1997, 16, 917 - 926.
  "Second Generation Antisense Oligonucleotides - Inhibition of PKC- and c-raf kinase expression by chimeric oligonucleotides incorporating 6'-substituted carbocyclic nucleotide and 2'-O-ethylene glycol substituted ribonucleotide units".
• K.-H. Altmann, R. Kesselring, U. Pieles, Tetrahedron 1996, 52, 12699 - 12722.
  "6'-Carbon-Substituted Carbocyclic Analogs of 2'-Deoxyribonucleosides - Synthesis and Effect on DNA/RNA Duplex Stability".
• K.-H. Altmann, M.-O. Bévierre, A. De Mesmaeker, H. E. Moser, Bioorg. Med. Chem. Lett. 1995, 5, 431 - 436.
  "The Evaluation of 2'- and 6'-Substituted Carbocyclic Nucleosides as Building Blocks for Antisense Oligonucleotides".
• A. De Mesmaeker, K.-H. Altmann, A. Waldner, S. Wendeborn, Curr. Opinion Struct. Biol. 1995, 5, 343 - 355.
  "Backbone-modified oligonucleotide analogs and PNA-like structures" (Review).
• K.-H. Altmann, R. Kesselring, E. Francotte, G. Rihs, Tetrahedron Lett. 1994, 35, 2331 - 2334.
  "4',6'-Methano carbocyclic thymidine: a conformationally constrained building block for oligonucleotides".
• K.-H. Altmann, S.M. Freier, U. Pieles, T. Winkler, Angew. Chem. Int. Ed. Engl. 1994, 33, 1654 - 1657.
  "Synthesis of an aza-thymidine and its incorporation into oligonucleotides".
• K.-H. Altmann, R. Kesselring, Synlett 1994, 853 - 856.
  "The synthesis of 1'-methyl carbocyclic thymidine and its effect on nucleic acid duplex stability".
• K.-H. Altmann, R. Imwinkelried, R. Kesselring, G. Rihs, Tetrahedron Lett. 1994, 35, 7625 - 7628.
  "1',6'-Methano carbocyclic thymidine: synthesis, X-ray crystal structure, and effect on nucleic acid duplex stability".
• C. Schmit, M.-O.Bévierre, A. De Mesmaeker, K.-H. Altmann, Bioorg. Med. Chem. Lett. 1994, 4, 1969 - 1974.
  "The Effects of 2'- and 3'-Alkyl Substituents on Oligonucleotide Hybridization and Stability".
• K.-H. Altmann, Tetrahedron Lett. 1993, 34, 7721 - 7724.
  "The synthesis of pyrrolidine based analogs of 3'-deoxy thymidine".