2000-2003

2003

• P. Furet, G. Bold, F. Hofmann, P. Manley, T. Meyer, K.-H. Altmann Bioorg. Med. Chem. Lett. 2003, 13, 2967–2971. “Identification of a New Chemical Class of Potent Angiogenesis Inhibitors Based on Conformational Considerations and Database Searching.”
• K. C. Nicolaou, P. K. Sasmal, G. Rassias, M. V. Reddy, K.-H. Altmann, M. Wartmann, A. O'Brate, P. Giannakakou Angew. Chem., Intl. Ed. 2003, 42, 3515-3520.
  “Design, synthesis, and biological properties of highly potent epothilone B analogues.”
• T. Carlomagno, M.J. J. Blommers, J. Meiler, W. Jahnke, T. Schupp, F. Petersen, D. Schinzer, K.-H. Altmann, C. Griesinger, Angew. Chem. 2003, 115, 2615-2619
  “The high-resolution solution structure of epothilone A bound to tubulin: An understanding of the structure-activity relationships for a powerful class of antitumor agents.”
• K.-H. Altmann Minirev. Med. Chem. 2003, 3, 149-158.
  “Epothilone B and its analogs – A new family of anticancer agents” (Review)

2002

• K.-H. Altmann, G. Bold, G. Caravatti, D. Denni, A. Flörsheimer, A. Schmidt, G. Rihs, M. Wartmann Helvetica Chimica Acta 2002, 85, 4086-4110. “The total synthesis and biological assessment of trans-epothilone A.”
• K.-H. Altmann, M. J. J. Blommers, G. Caravatti, A. Flörsheimer, K. C. Nicolaou, T. O’Reilly, A. Schmidt, D. Schinzer, and M. Wartmann in “Anticancer Agents – Frontiers in Cancer Chemotherapy”, Ojima, I.; Vite G.D.; Altmann, K.-H., Eds., ACS Symposium Series 796, American Chemical Society, Washington DC, 2001, pp.112-130. “Synthetic and Semi-Synthetic Analogs of Epothilones - Chemistry and Biological Activity.”
• M. Wartmann, K.-H. Altmann Curr. Rev. Med. Chem. – Anticancer Agents 2002, 2, 123-148. “The Biology and Medicinal Chemistry of Epothilones.” (Review)
• K. C. Nicolaou, A. Ritzen, K. Namoto, R. M. Buey, J. M. Andreu, M. Wartmann, K.-H. Altmann, A. O’Brate, P. Giannakakou Tetrahedron 2002, 58, 6413-6432. “Chemical synthesis and biological evaluation of novel epothilone B and trans-12,13-cyclopropyl epothilone B analogues.”
• G. Koch, O. Loiseleur, D. Fuentes, A. Jantsch, K.-H. Altmann Organic Letters 2002, 4, 3811-3814. “Diastereoselective titanium enolate aldol reaction for the total synthesis of epothilones.”

2001

• K. C. Nicolaou, K. Namoto, A. Ritzen, T. Ulven, M. Shoji, J. Li, G. D'Amico, D. Liotta, C. T. French, M. Wartmann, K.-H. Altmann, P. Giannakakou J. Am. Chem. Soc. 2001, 123, 9313-9323 “Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues.”
• K.-H. Altmann Curr. Opin. Chem. Biol. 2001, 5, 424-431 “Microtubule-stabilizing agents: a growing class of important anticancer drugs.” (Review)
• A. Flörsheimer, K.-H. Altmann Expert Opin. Ther. Pat. 2001, 11, 951-968. “Epothilones and their analogues - a new class of promising microtubule inhibitors.”
  (Review)
• C. J. Wilds, G. Minasov, F. Natt, P. von Matt, K.-H. Altmann, M. Egli Nucleosides, Nucleotides & Nucleic Acids 2001, 20, 991-994. “Studies of a chemically modified oligodeoxynucleotide containing A 5-atom amide backbone which exhibits improved binding to RNA.”

2000

• D. Schinzer, K.-H. Altmann, F. Stuhlmann, A. Bauer, M. Wartmann ChemBioChem 2000, 1, 67-70. “Synthesis and biological evaluation of aza-epothilones.”
• N. End, G. Bold, G. Caravatti, M. Wartmann, K.-H. Altmann Proc. ECSOC-4, 2000, 2000, Meeting Date 2000, 1431-1442. “Synthetic epothilone analogs with modifications in the northern hemisphere and the heterocyclic side-chain-synthesis and biological evaluation.”
• D. Schinzer, K.-H. Altmann, F. Stuhlmann, A. Bauer, M. Wartmann ChemBioChem 2000, 1, 67-70. “Synthesis and biological evaluation of aza-epothilones.”
• K. C. Nicolaou, R. Scarpelli, B. Bollbuck, B. Werschkun, M. M. A. Pereira, M. Wartmann, K.-H. Altmann, D. Zaharevitz, R. Gussio, P. Giannakakou Chem. Biol. 2000, 7, 593-599. “Chemical synthesis and biological properties of pyridine epothilones.”
• K.-H. Altmann, G. Bold, G. Caravatti, N. End, A. Flörsheimer, V. Guagnano, T. O’Reilly, M. Wartmann Chimia 2000, 54, 612 - 621. “Epothilones and their analogs - potential new weapons in the fight against cancer.”
• K.-H. Altmann, G. Bold, G. Caravatti, A. Flörsheimer, V. Guagnano, M. Wartmann Bioorg. Med. Chem Lett. 2000, 10, 2765 - 2768. “Synthesis and biological evaluation of highly potent analogues of epothilones B and D.”
• K.-H. Altmann, M. Wartmann, T. O’Reilly, published online in Reviews on Cancer Online. Paper edition: Biochimica et Biphysica Acta 2000, 1470, M79-M71. “Epothilones and Related Structures - A new Class of Microtubule Inhibitors with Potent in vivo Antitumor Activity”.
• G. Bold, K.-H. Altmann, J. Frei, M. Lang, P. W. Manley, P. Traxler, B. Wietfeld, J. Brueggen, E. Buchdunger, R. Cozens, S. Ferrari, P. Furet, F. Hofmann, G. Martiny-Baron, J. Mestan, J. Roesel, M. Sills, D. Stover, F. Acemoglu, E. Boss, R. Emmenegger, L. Laesser, E. Masso, R. Roth, C. Schlachter, W. Vetterli, D. Wyss, J. M. Wood J. Med. Chem. 2000, 43, 2310. “New Anilinophthalazines as Potent and Orally Well Absorbed Inhibitors of the VEGF Receptor Tyrosine Kinases Useful as Antagonists of Tumor-Driven Angiogenesis.”