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2004-2005
Research Networks
Recent Publications
- Diversity through semisynthesis: the chemistry and biological activity of semisynthetic epothilone derivatives. Altmann, K.-H., Gaugaz, F. Z., Schiess, R. Mol. Divers. 2011, 15, 383-399.
- Stereoselective Synthesis of 12,13-Cyclopropyl-Epothilone B and Side-Chain-Modified Variants. R. Schiess, R., Gertsch, J., Schweizer, W. B., Altmann. K.-H. Org. Lett., 2011, 13, 1436-1439.
- Kinase Inhibition by Deoxy Analogs of the Resorcylic Lactone L-783277. Liniger, M., Neuhaus, C., Hofmann, T., Fransioli-Ignazio, L., Jordi, M., Drueckes, P., Trappe, J., Fabbro, D., Altmann, K.-H. ACS Med. Chem. Lett., 2011, 2, 22-27.
2005
- T. O’Reilly, F. Wenger, M. Hattenberger, J. Vaxelaire, M. Muller, P. M. J. McSheehy, K.-H. Altmann, M. Wartmann The Prostate 2005, in press.
“Patupilone (epothilone B, EPO906) inhibits growth and metastasis of experimental prostate tumors in vivo” - T. O’Reilly, M. Wartmann, S.-M. Maira, M. Hattenberger, J. Vaxelaire, M. Muller,
E. Buchdunger, K.-H. Altmann, P. M. J. McSheehy Cancer Chemother. Pharmcol. 2005, 55, 307-317.
“Patupilone (Epothilone B, EPO906) and imatinib (STI571, Glivec®) in combination display enhanced antitumour activity in vivo against experimental rat C6 glioma” - K.-H. Altmann Curr. Pharm. Design 2005, 11, 1595-1614. (Invited review)
“Recent developments in the chemical biology of epothilones“
2004
- F. Cachoux, F. Schaal, A. Teichert, T. Wagner, K.-H. Altmann Synlett 2004, 2709-2712.
“Synthesis of 4-Aza Analogs of Epothilone D.” - N. End, P. Furet, N. van Campenhout, M. Wartmann, K.-H. Altmann Chem. & Biodiversity 2004, 1, 1771-1784.
“Total Synthesis and Biological Evaluation of a C(10)/C(12)-Phenylene-bridged Analog of Epothilone D.” - K.-H. Altmann, A. Flörsheimer, G. Bold, G. Caravatti, M. Wartmann Chimia 2004, 58, 686-690. (Invited Review)
”Natural Product-based Drug Discovery - Epothilones as Lead Structures for the Discovery of New Anticancer Agents” - K.-H. Altmann Org. Bioorg. Chem. 2004, 2137-2152. (Invited review)
“The Merger between Medicinal Chemistry and Natural Product Synthesis: On the Chemistry and Chemical Biology of Epothilones.” - D. Schinzer, O. Böhm, K.-H. Altmann, M. Wartmann Synlett 2004, 1375-1378.
“Synthesis and biological evaluation of furano-epothilone C.” - G. Koch, O. Loiseleur, D. Fuentes, A. Jantsch, K.-H. Altmann Synlett 2004, 693-697.
“Total Synthesis of 26-Fluoro-Epothilone B.”
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