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2006
Recent Publications
- Diversity
through semisynthesis: the chemistry and biological activity of semisynthetic
epothilone derivatives. Altmann,
K.-H., Gaugaz, F. Z., Schiess, R. Mol.
Divers. 2011, 15, 383-399.
- Stereoselective
Synthesis of 12,13-Cyclopropyl-Epothilone B and Side-Chain-Modified Variants. R. Schiess,
R., Gertsch, J., Schweizer, W. B., Altmann. K.-H. Org.
Lett., 2011, 13, 1436-1439.
- Kinase
Inhibition by Deoxy Analogs of the Resorcylic Lactone L-783277. Liniger,
M., Neuhaus, C., Hofmann, T., Fransioli-Ignazio, L., Jordi,
M., Drueckes, P., Trappe, J., Fabbro, D., Altmann, K.-H. ACS
Med. Chem. Lett., 2011, 2, 22-27.
- J. Gertsch, S. Raduner, K.-H. Altmann J Recept Signal Transduct Res. 2006;26(5-6):709-30.
"New natural noncannabinoid ligands for cannabinoid type-2 (CB2) receptors."
- F. Feyen, J. Gertsch, M. Wartmann, K.-H. Altmann Angew Chem Int Ed Engl. 2006 Sep 4;45(35):5880-5.
"Design and synthesis of 12-aza-epothilones (azathilones)--"non-natural" natural products with potent anticancer activity."
- PS. Pallan, P. von Matt, CJ. Wilds, K.-H. Altmann, M. Egli Biochemistry. 2006 Jul 4;45(26):8048-57.
"RNA-Binding affinities and crystal structure of oligonucleotides containing five-atom amide-based backbone structures."
- S. Raduner, A. Majewska, JZ. Chen, XQ. Xie, J. Hamon, B. Faller, K.-H. Altmann, J. Gertsch J Biol Chem. 2006 May 19;281(20):14192-206. Epub 2006 Mar 17.
"Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects."
- F. Cachoux, T. Isarno, M. Wartmann, K.-H. Altmann Chembiochem. 2006 Jan;7(1):54-7.
"Total synthesis and biological assessment of benzimidazole-based analogues of epothilone A: ambivalent effects on cancer cell growth inhibition."
- G. Bold, S. Wojeik, G. Caravatti, R. Lindauer, C. Stierlin, J. Gertsch, M. Wartmann, K.-H. Altmann ChemMedChem. 2006 Jan;1(1):37-40.
"Structure-activity relationships in side-chain-modified epothilone analogues--how important is the position of the nitrogen atom?"
- Altmann, Karl-Heinz. The chemistry and biology of epothilones-lead structures for the discovery of improved microtubule inhibitors. Medical Chemistry of Bioactive Natural Products (2006), 1-34.
- Altmann, Karl-Heinz. Anticancer Agents from Natural Products edited by Gordon Cragg, David Kingston and David Newman. Angewandte Chemie, International Edition (2006), 45(38), 6248-6249.
- Gertsch, Jurg; Raduner, Stefan; Altmann, Karl-Heinz. New natural noncannabinoid ligands for cannabinoid type-2 (CB2) receptors. Journal of Receptors and Signal Transduction (2006), 26(5-6), 709-730.
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