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2008
Research Networks
Recent Publications
- Diversity through semisynthesis: the chemistry and biological activity of semisynthetic epothilone derivatives. Altmann, K.-H., Gaugaz, F. Z., Schiess, R. Mol. Divers. 2011, 15, 383-399.
- Stereoselective Synthesis of 12,13-Cyclopropyl-Epothilone B and Side-Chain-Modified Variants. R. Schiess, R., Gertsch, J., Schweizer, W. B., Altmann. K.-H. Org. Lett., 2011, 13, 1436-1439.
- Kinase Inhibition by Deoxy Analogs of the Resorcylic Lactone L-783277. Liniger, M., Neuhaus, C., Hofmann, T., Fransioli-Ignazio, L., Jordi, M., Drueckes, P., Trappe, J., Fabbro, D., Altmann, K.-H. ACS Med. Chem. Lett., 2011, 2, 22-27.
- Epothilones as Lead Structures for the Synthesis-Based Discovery of New Chemotypes for Microtubule Stabilization. Feyen, Fabian; Cachoux, Frederic; Gertsch, Juerg; Wartmann, Markus; Altmann, Karl-Heinz. Accounts of Chemical Research (2008), 41(1), 21-31.
- Total Synthesis of Hypermodified Epothilone Analogs with Potent in Vitro Antitumor Activity. Kuzniewski, Christian N.; Gertsch, Juerg; Wartmann, Markus; Altmann, Karl-Heinz. Organic Letters (2008), 10(6), 1183-1186.
- Conformational preferences of natural and C3-modified epothilones in aqueous solution. Erdélyi M, Pfeiffer B, Hauenstein K, Fohrer J, Gertsch J, Altmann KH, Carlomagno T. J Med Chem. 2008 Mar 13;51(5):1469-73.
- Epothilones as lead structures for new anticancer drugs--pharmacology, fermentation, and structure-activity-relationships. Altmann KH, Memmert K. Prog Drug Res. 2008;66:273, 275-334.
- Unraveling a molecular target of macrolides. Altmann KH, Carreira EM. Nat Chem Biol. 2008 Jul;4(7):388-9.
- Beta-caryophyllene is a dietary cannabinoid. Gertsch J, Leonti M, Raduner S, Racz I, Chen JZ, Xie XQ, Altmann KH, Karsak M, Zimmer A. Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9099-104.
- Total synthesis of the marine diterpenoid blumiolide C. Hamel C, Prusov EV, Gertsch J, Schweizer WB, Altmann KH. Angew Chem Int Ed Engl. 2008;47(52):10081-5.
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