2009

• GABA A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. Benke D, Barberis A, Kopp S, Altmann KH, Schubiger M, Vogt KE, Rudolph U, Möhler H. Neuropharmacology. 2009 Jan;56(1):174-81.
• Differential effects of natural product microtubule stabilizers on microtubule assembly: single agent and combination studies with taxol, epothilone B, and discodermolide. Gertsch J, Meier S, Müller M, Altmann KH. Chembiochem. 2009 Jan 5;10(1):166-75.
• The state of the art of chemical biology. Altmann KH, Buchner J, Kessler H, Diederich F, Kräutler B, Lippard S, Liskamp R, Müller K, Nolan EM, Samori B, Schneider G, Schreiber SL, Schwalbe H, Toniolo C, van Boeckel CA, Waldmann H, Walsh CT. Chembiochem. 2009 Jan 5;10(1):16-29.
• Discovery of novel CB2 receptor ligands by a pharmacophore-based virtual screening workflow. Markt P, Feldmann C, Rollinger JM, Raduner S, Schuster D, Kirchmair J, Distinto S, Spitzer GM, Wolber G, Laggner C, Altmann KH, Langer T, Gertsch J. J Med Chem. 2009 Jan 22;52(2):369-78.
• Semisynthetic derivatives of epothilones. Altmann KH. Fortschr Chem Org Naturst. 2009;90:135-56
• Preclinical pharmacology and structure-activity studies of epothilones. Altmann KH. Fortschr Chem Org Naturst. 2009;90:157-220.
• Clinical studies with epothilones. Altmann KH. Fortschr Chem Org Naturst. 2009;90:221-37.
• Synergistic immunomopharmacological effects of N-alkylamides in Echinacea purpurea herbal extracts. Chicca A, Raduner S, Pellati F, Strompen T, Altmann KH, Schoop R, Gertsch J. Int Immunopharmacol. 2009 Jul;9(7-8):850-8. Epub 2009 Mar 19.
• The laulimalide family: total synthesis and biological evaluation of neolaulimalide, isolaulimalide, laulimalide and a nonnatural analogue. Gollner A, Altmann KH, Gertsch J, Mulzer J. Chemistry. 2009 Jun 8;15(24):5979-97.
• Synthesis and SAR of C12-C13-oxazoline derivatives of epothilone A. Pfeiffer B, Hauenstein K, Merz P, Gertsch J, Altmann KH. Bioorg Med Chem Lett. 2009 May 3.
• Editorial. Altmann KH, Neri D. Curr Opin Chem Biol. 2009 Jun 23.
• Total Synthesis of Valerenic Acid. Kopp S, W. Bernd Schweizer W.B., Altmann K-H. Synlett 2009;11:1769-1772
• Epothilone Analogs with Benzimidazole and Quinoline Side Chains: Chemical Synthesis, Antiproliferative Activity, and Interactions with Tubulin. Dietrich, S., Lindauer, R., Stierlin, C., Gertsch, J., Matesanz, R., Notararigo, S., Díaz, J. F., Altmann, K.-H. Chem. Eur. J. 2009, 10144-10157.
• Macrolide-Based Microtubule-Stabilizing Agents – Chemistry and Structure–Activity Relationships. Pfeiffer, B., Kuzniewski, C. N., Wullschleger, C., Altmann, K.-H. Top. Curr. Chem., 2009, 86, 1-72.
• Making Epothilones Fluoresce: Design, Synthesis, and Biological Characterization of a Fluorescent N¹²-Aza-Epothilone (Azathilone). Gertsch, J., Feyen, F., Bützberger, A., Gerber, B., Pfeiffer, B., Altmann, K.-H. ChemBioChem, 2009, 2513-2521.
• Synthesis and biological evaluation of epothilone A dimeric compounds. Passarella, D., Comi, D., Cappelletti, G., Cartelli, D., Gertsch, J., Quesada, A. R., Borlak, J., Altmann, K.-H. Bioorg. Med. Chem., 2009, 17, 7435-7440.
• Synthesis and biological evaluation of a des-dihydropyran laulimalide analog. Gollner, A., Altmann, K.-H., Gertsch, J., Mulzer, J. Tetrahedron Lett., 2009, 50, 5790-5792.
• Resorcylic acid lactone L-783,277 inhibits the growth of the human adrenal cancer cell line H295R in vitro. Int. J. Immunopathol. Pharmacol., 2009, 22, 889-895.
• Altmann, K.-H., Neri, D., Curr. Opin. Chem. Biol., 2009, 13, 231-234. (Editorial as guest editors of a journal issue on Next Generation Therapeutics).
• Altmann, K.-H., Clinical Studies with Epothilones. In: The Epothilones: An Outstanding Family of Anti-Tumor Agents, Progr. Chem. Org. Nat. Prod. 90, A. D. Kinghorn, H. Falk, J. Kobayashi, Eds., Springer Wien New York, 2009, pp. 221-238. (Book chapter).
• Altmann, K.-H., Preclinical Pharmacology and Structure-Activity Studies of Epothilones. In: The Epothilones: An Outstanding Family of Anti-Tumor Agents, Progr. Chem. Org. Nat. Prod. Vol. 90, A. D. Kinghorn, H. Falk, J. Kobayashi, Eds., Springer Wien New York, 2009, pp. 157-220. (Book chapter).
• Altmann, K.-H., Semisynthetic Derivatives of Epothilones. In: The Epothilones: An Outstanding Family of Anti-Tumor Agents, Progr. Chem. Org. Nat. Prod. 90, A. D. Kinghorn, H. Falk, J. Kobayashi, Eds., Springer Wien New York, 2009, pp. 135-156. (Book chapter).