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2010
Research Networks
Recent Publications
- Diversity through semisynthesis: the chemistry and biological activity of semisynthetic epothilone derivatives. Altmann, K.-H., Gaugaz, F. Z., Schiess, R. Mol. Divers. 2011, 15, 383-399.
- Stereoselective Synthesis of 12,13-Cyclopropyl-Epothilone B and Side-Chain-Modified Variants. R. Schiess, R., Gertsch, J., Schweizer, W. B., Altmann. K.-H. Org. Lett., 2011, 13, 1436-1439.
- Kinase Inhibition by Deoxy Analogs of the Resorcylic Lactone L-783277. Liniger, M., Neuhaus, C., Hofmann, T., Fransioli-Ignazio, L., Jordi, M., Drueckes, P., Trappe, J., Fabbro, D., Altmann, K.-H. ACS Med. Chem. Lett., 2011, 2, 22-27.
- The Binding Mode of Side Chain- and C3-Modified Epothilones to Tubulin. Erdelyi, M., Navarro-Vazquez, A., Pfeiffer, B., Kuzniewski, C. N., Felser, A., Widmer, T., Gertsch, J., Pera, B., Diaz, J. F., Altmann, K.-H., T. Carlomagno, T., ChemMedChem, 2010, 5, 911-920.
- Identification of serotonin 5-HT1A receptor partial agonists in ginger. Nievergelt, A., Huonker, P., Schoop, R., Altmann, K.-H. Bioorg. Med. Chem., 2010, 18, 3345-3351.
- Highly Potent Modulation of GABAA Receptors by Valerenic Acid Derivatives. Kopp, S., Baur, R., Sigel, E., Moehler, H., Altmann, K.-H. ChemMedChem, 2010, 5, 678-681.
- Synthesis of (-)-Dactylolide and 13-Desmethylene-(-)-dactylolide and Their Effects on Tubulin. Zurwerra, D., Gertsch, J., Altmann, K.-H. Org. Lett., 2010, 12, 2302-2305.
- Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin. Leonti, M., Casu, L., Raduner, S., Cottiglia, F., Floris, C., Altmann, K.-H., Gertsch, J. Biochem. Pharmacol., 2010, 79, 1815-1826.
- Stereoselective Synthesis of a Monocyclic Peloruside A Analogue. Wullschleger, C. W., Gertsch, J., Altmann, K.-H. Org. Lett., 2010, 12, 1120-112.
- Evaluation of Novel Epothilone Analogues by means of a Common Pharmacophore and a QSAR Pseudoreceptor Model for Taxanes and Epothilones. Forli, S., Manetti, F., Altmann, K.-H., Botta, M. ChemMedChem, 2010, 5, 35-40.
- Treasures from the Sea: Discovery and Total Synthesis of Ammosamides. Zurwerra, D., Wullschleger, C. W., Altmann, K.-H. Angew. Chem. Int. Ed., 2010, 49, 6936-6938.
- Synthesis and biological activity of new functionalized epothilones for prodrug design and tumor targeting. Anthoine Dietrich, S., Riediker, L., Gertsch, J., Altmann, K.-H. Chimia, 2010, 64, 136-139.
- Natural products as leads for anticancer drug discovery: discovery of new chemotypes of microtubule stabilizers through reengineering of the epothilone scaffold. Altmann, K.-H., Cachoux, F., Feyen, F., Gertsch, J., Kuzniewski, C. N., Wartmann, M. Chimia, 2010, 64, 8-13.
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