Publications

Selected publications of relevance

Properties of N⁴-methylated cytidines in miRNA mimics
B. Guennewig, M. Stoltz, M. Menzi, A. M. Dogar, J. Hall
Nucleic Acid Therapeutics (2012) accepted.

A Decade of the Human Genome Sequence----How Does the Medicinal Chemist Benefit.
A. Brunschweiger, J. Hall.
ChemMedChem (2012) in press.

Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28.
F.E. Loughlin, L.F.R. Gebert, H. Towbin, A. Brunschweiger, J. Hall, F.H-T. Allain.
Nature Structural & Molecular Biology (2012), 19, 84-89.

Suppression of latent Tgf-beta1 restores growth inhibitory Tgf-beta signaling through microRNAs.
Dogar, A. M.; Towbin, H.; Hall, J.
Journal of Biological Chemistry (2011) 286, 16447-16458

Genomics drugs in clinical trials
Hall, J.; Dennler, P.; Haller, S.; Pratsinis, A.; Sauberli, K.; Towbin, H.; Walther, K.; Woytschak, J.
Nature Reviews Drug Discovery (2010), 9(12), 988.

Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction.
Fumagalli, S.; Di Cara, A.; Neb-Gulati, A.; Natt, F.; Schwemberger, S.; Hall, J.; Babcock, G. F.; Bernardi, R.; Pandolfi, Pier P.; Thomas, G.
Nature Cell Biology (2009), 11(4), 501-508.

Whole genome functional analysis identifies novel components required for mitotic spindle integrity in human cells.
Rines, D. R.; Gomez-Ferreria, M.A.; Zhou, Y.; Paul, D.; Grob, S.; Batalov, S.; Labow, M.; Huesken, D.; Mickanin, C.; Hall, J.; Reinhardt, M.; Natt, F.; Lange, J.; Sharp, D. J.; Chanda, S. K.; Caldwell, J.
GenomeBiology (2008), 9(2), R44/1-R44/11

A novel microarray approach reveals new tissue-specific signatures of known and predicted mammalian microRNAs.
Beuvink, I.; Kolb, F. A.; Budach, W.; Garnier, A.; Lange, J.; Natt, F.; Dengler, U.; Hall, J.; Filipowicz, W.; Weiler, J.
Nucleic Acids Research (2007), 35(7), e52/1-e52/11

Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease?
Weiler, J.; Hunziker, J.; Hall, J.
Gene Therapy (2006) 13, 496 – 502.

Genome-wide functional analysis of human cell-cycle regulators.
Mukherji, M.; Bell, R.; Supekova, L.; Wang, Y.; Orth, A. P.; Batalov, S.; Miraglia, L.; Huesken, D.; Lange, J.; Martin, C.; Sahasrabudhe, S.; Reinhardt, M.; Natt, F.; Hall, J.; Mickanin, C.; Labow, M.; Chanda, S. K.; Cho, C. Y.; Schultz, P. G.
Proceedings of the National Academy of Sciences of the United States of America (2006), 103(40), 14819-14824.

Application of RNAi in biomedical research.
Hall, J.
Chimia (2005), 59(11), 803-807.

ADP-ribose-1''-monophosphatase: A conserved coronavirus enzyme that is dispensable for viral replication in tissue culture.
Putics, A.; Filipowicz, W.; Hall, J.; Gorbalenya, A. E.; Ziebuhr, J.
Journal of Virology (2005), 79(20), 12721-12731.

Design of a genome-wide siRNA library using an artificial neural network.
Huesken, D.; Lange, J.; Mickanin, C.; Weiler, J.; Asselbergs, F.; Warner, J.; Meloon, B.; Engel, S.; Rosenberg, A.; Cohen, D.; Labow, M.; Reinhardt, M.; Natt, F.; Hall, J.
Nature Biotechnology (2005), 23(8), 995-1001.

The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.
Beuvink, I.; Boulay, A.; Fumagalli, S.; Zilbermann, F.; Ruetz, S.; O'Reilly, T.; Natt, F.; Hall, J.; Lane, H. A.; Thomas, G.
Cell (Cambridge, MA, United States) (2005), 120(6), 747-759.

The human ubiquitin-conjugating enzyme Cdc34 controls cellular proliferation through regulation of p27Kip1 protein levels.
Butz, N.; Ruetz, S.; Natt, F.; Hall, J.; Weiler, J.; Mestan, J.; Ducarre, M.; Grossenbacher, R.; Hauser, P.; Kempf, D.; Hofmann, F.
Experimental Cell Research (2005), 303(2), 482-493.

Opinion: Unravelling the general properties of siRNAs: strength in numbers and lessons from the past.
Hall, J.
Nature Reviews Genetics (2004), 5(7), 552-557.

Potential applications of siRNA for pain therapy.
Ganju, P.; Hall, J.
Expert Opinion on Biological Therapy (2004), 4(4), 531-542.

siRNA relieves chronic neuropathic pain.
Dorn, G.; Patel, S.; Wotherspoon, G.; Hemmings-Mieszczak, M.; Barclay, J.; Natt, F. J. C.; Martin, P.; Bevan, S.; Fox, A.; Ganju, P.; Wishart, W.; Hall, J.
Nucleic Acids Research (2004), 32(5), e49/1-e49/6.

A novel oxime-derived solid support for the synthesis of 3-phosphorylated oligonucleotides.
Langenegger, S. M.; Moesch, L.; Natt, F.; Hall, J.; Haener, R.
Helvetica Chimica Acta (2003), 86(10), 3476-3481.

mRNA fusion constructs serve in a general cell-based assay to profile oligonucleotide activity.
Huesken, D.; Asselbergs, F.; Kinzel, B.; Natt, F.; Weiler, J.; Martin, P.; Haener, R.; Hall, J.
Nucleic Acids Research (2003), 31(17), e102/1-e102/11.

Independent combinatorial effect of antisense oligonucleotides and RNAi-mediated specific inhibition of the recombinant rat P2X3 receptor.
Hemmings-Mieszczak, M.; Dorn, G.; Natt, F. J.; Hall, J.; Wishart, W. L.
Nucleic Acids Research (2003), 31(8), 2117-2126.

Bcl-2/bcl-xL Bispecific Antisense Treatment Sensitizes Breast Carcinoma Cells to Doxorubicin, Paclitaxel and Cyclophosphamide.
Simoes-Wuest, A. P.; Schuerpf, T.; Hall, J.; Stahel, R. A.; Zangemeister-Wittke, U.
Breast Cancer Research and Treatment (2002), 76(2), 157-166.

Functional downregulation of P2X3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain.
Barclay, J.; Patel, S.; Dorn, G.; Wotherspoon, G.; Moffatt, S.; Eunson, L.; Abdel'al, S.; Natt, F.; Hall, J.; Winter, J.; Bevan, S.; Wishart, W.; Fox, A.; Ganju, P.
Journal of Neuroscience (2002), 22(18), 8139-8147.

Artificial ribonucleases: Efficient and specific in vitro cleavage of human c-raf-1 RNA.
Canaple, L.; Huesken, D.; Hall, J.; Haener, R.
Bioconjugate Chemistry (2002), 13(5), 945-951.

Analysis of ribosyl-modified, mixed backbone analogs of a bcl-2/bcl-xL antisense oligonucleotide.
Olie, R. A.; Hall, J.; Natt, F.; Stahel, R. A.; Zangemeister-Wittke, U.
Biochimica et Biophysica Acta, Gene Structure and Expression (2002), 1576(1-2), 101-109.

Consequences of the inhibition of Hdm2 expression in human osteosarcoma cells using antisense oligonucleotides.
Geiger, T.; Huesken, D.; Weiler, J.; Natt, F.; Woods-Cook, K. A.; Hall, J.; Fabbro, D.
Anti-Cancer Drug Design (2001), Volume Date 2000, 15(6), 423-430.

Specific inhibition of the rat ligand-gated ion chA.l P2X3 function via methoxyethoxy-modified phosphorothioated antisense oligonucleotides.
Dorn, G.; Abdel'al, S.; Natt, F. J. C.; Weiler, J.; Hall, J.; Meigel, I.; Mosbacher, J.; Wishart, W.
Antisense & Nucleic Acid Drug Development (2001), 11(3), 165-174.

Activity of a novel bcl-2/bcl-xL-bispecific antisense oligonucleotide against tumors of diverse histologic origins.
Gautschi, O.; Tschopp, S.; Olie, R. A.; Leech, S. H.; Simoes-Wust, A. P.; Ziegler, A. M.; Baumann, B.; Odermatt, B.; Hall, J.; Stahel, R. A.; Zangemeister-Wittke, U.
Journal of the National Cancer Institute (2001), 93(6), 463-471

Induction of apoptosis in lung-cancer cells following bcl-xL anti-sense treatment.
Leech, S. H.; Olie, R. A.; Gautschi, O.; Simoes-Wust, A. P.; Tschopp, S.; Haener, R.; Hall, J.; Stahel, R. A.; Zangemeister-Wittke, U.
International Journal of Cancer (2000), 86(4), 570-576.

Sequence-specific cleavage of RNA using macrocyclic lanthanide complexes conjugated to oligonucleotides: a structure activity study.
Hall, J.; Huesken, D.; Haener, R.
Nucleosides & Nucleotides (1997), 16(7-9), 1357-1368.

The sequence-specific cleavage of RNA by artificial chemical ribonucleases.
Haener, R.; Hall, J.
Antisense & Nucleic Acid Drug Development (1997), 7(4), 423-430.

Cloning and characterization of the Arabidopsis cyclic phosphodiesterase which hydrolyzes ADP-ribose 1'',2''-cyclic phosphate and nucleoside 2',3'-cyclic phosphates.
Genschik, P.; Hall, J.; Filipowicz, W.
Journal of Biological Chemistry (1997), 272(20), 13211-13219.

Synthesis and structure of a macrocyclic europium complex and its possible role as a catalyst for phosphodiester transesterification.
Haener, R.; Hall, J.; Rihs, G.
Helvetica Chimica Acta (1997), 80(2), 487-494.

Creating RNA Bulges: Cleavage of RNA in RNA/DNA Duplexes by Metal Ion Catalysis. Huesken, D.; Goodall, G.; Blommers, M. J. J.; Jahnke, W.; Hall, J.; Haener, R.; Moser, H. E.
Biochemistry (1996), 35(51), 16591-16600.

Towards artificial ribonucleases: the sequence-specific cleavage of RNA in a duplex.
Hall, J.; Huesken, D.; Haener, R.
Nucleic Acids Research (1996), 24(18), 3522-3526.

Linear tris-terpyridines and their trinuclear Ru(II) complexes: synthesis, absorption spectra, and excited state properties.
Hasenknopf, B.; Hall, J.; Lehn, J.-M.; Balzani, V.; Credi A.; Campagna, S.
New Journal of Chemistry (1996), 20(7-8), 725-730.

Synthesis and characterization of the (5'- 5'')-ester of adenosine 5'-diphosphate with a -D-ribofuranose cyclic 1'',2''-phosphate, a NAD derivative produced during tRNA splicing.
Hall, J.; Genschik, P.; Filipowicz, W.
Helvetica Chimica Acta (1996), 79(4), 1005-1010.

Efficient sequence-specific cleavage of RNA using novel europium complexes conjugated to oligonucleotides.
Hall, J.; Huesken, D.; Pieles, U.; Moser, H. E.; Haener, R.
Chemistry & Biology (1994), 1(3), 185-90.