Publications

Publications                                           

2011

• Mumprecht V, Roudnicky F, Detmar M. Inflammation-induced lymph node lymphangiogenesis is reversible. Am J Pathol, in press.
• Proulx S, Detmar M. Watching lymphatic vessels grow by making them glow. Cell Research, epub
• Niederer F, Trenkmann M, Ospelt C, Karouzakis E, Neidhart M, Stanczyk J, Kolling Ch, Detmar M, Gay S, Jüngel A, Kyburz D. Downregulation of microRNA-34a* in rheumatoid arthritis synovial fibroblasts promotes apoptosis resistance. Arthritis & Rheumatisms, in press
• Christiansen A, Detmar M. Lymphangiogenesis and Cancer. Genes & Cancer, in press
• Huggenberger R., Detmar M. (2011) The Cutaneous Vascular System in Chronic Skin Inflammation. J Invest Dermatol Symp Proc, 15: 24-32
• Chan JY, Koon JC, Liu X, Detmar M, Yu B, Kong SK, Fung KP. (2011) Polyphyllin D, a steroidal saponin from Paris polyphylla, inhibits endothelial cell functions in vitro and angiogenesis in zebrafish embryos in vivo. J Ethnopharmacol. 1;137: 64-9.
• Niederer F, Ospelt C, Brentano F, Hottiger MO, Gay RE, Gay S, Detmar M, Kyburz D. (2011) SIRT1 overexpression in the Rheumatoid Arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance, Ann Rheum Dis, 70: 1866-73
• Christiansen AJ, West A, Banks KM, Haynes NM, Teng MW, Smyth MJ, Johnstone RW, (2011) Eradication of solid tumors using histone deacetylase inhibitors combined with immune-stimulating antibodies. Proc Natl Acad Sci USA, 108: 4141-6
• Kerjaschki D, Rudas M, Bartel G, Bago-Horvath Z, Sexl V, Wolbank S, Schneckenleithner Ch, Dolznig H, Krieger S, Hantusch B, Nagy-Bojarszky K, Huttary N, Raab I, Kalt R, Lackner K, Hämmerle M, Keller T, Viola K, Schreiber M, Nader A, Mikulits W, Gnant M, Krautgasser K, Schachner H, Kaserer K, Rezar S, Madlener S, Vonach C, Davidovits A, Nosaka H, Hirakawa S, Detmar M, Alitalo K, Nijman S, Offner F, Maier TJ, Steinhilber D, Krupitza. G. (2011) Lipoxygenase driven tumor cell invasion of intrametastatic lymphatic vessels propagates lymph node metastasis of human carcinomas. J Clin Invest, 121: 2000-12
• Huggenberger R, Siddiqui S, Brander D, Ullmann S, Zimmermann K, Antsiferova M, Werner S, Alitalo K, Detmar M. (2011) An important role of lymphatic vessel activation in limiting acute inflammation. Blood, 117: 4667-78
• Marino D, Dabouras V, Brandli A, Detmar M. (2011) A role for all-trans-retinoic acid in the early steps of lymphatic vasculature development. J Vasc Res, 48: 236-251

2010

• Mumprecht V, Honer M, Vigl B, Proulx ST, Trachsel E, Kaspar M, Banziger-Tobler NE, Schibli R, Neri D, Detmar M. (2010) In vivo imaging of inflammation- and tumor-induced lymph node lymphangiogenesis by immuno-positron emission tomography. Cancer Res, 70: 8842-51.
• Cueni L, Chen L, Zhang H, Marino D, Huggenberger R, Alitalo A, Bianchi R, Detmar M. (2010) Podoplanin-Fc reduces lymphatic vessel formation in vitro and in vivo and causes disseminated intravascular coagulation when transgenically expressed in the skin, Blood, 116: 4376-4384.
• Proulx ST, Luciani P, Derzsi S, Rinderknecht M, Mumprecht V, Leroux J-Ch, Detmar M. (2010) Quantitative Imaging of Lymphatic Function with Liposomal Indocyanine Green. Cancer Res, 70: 7053-62.
• Huggenberger R, Ullmann S, Proulx ST, Pytowski B, Alitalo K, Detmar M. (2010) Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation. J Exp Med,  207: 2255-69.
• Rinderknecht M, Villa A, Ballmer-Hofer K, Neri D, Detmar M. (2010) Phage-derived fully human monoclonal antibody fragments to human vascular endothelial growth factor-C block its interaction with both VEGF receptor-2 and VEGF receptor 3, PLoSONE, 5: e11941
• Jurisic G, Iolyeva M, Proulx St, Halin C, Detmar M. Thymus cell antigen 1 (Thy1, CD90) is expressed by lymphatic vessels and mediates cell adhesion to lymphatic endothelium. Exp Cell Res. 316: 2982-92.
• Leslie Pedrioli DM, Karpanen T, Dabouras V, Jurisic G, van de Hoek G, Shin JW, Marino D, Kälin RE, Leidel S, Cinelli P, Schulte-Merker S, Brändli AW, Detmar M. (2010) miR-31 functions as a negative regulator of lymphatic vascular lineage-specific differentiation in vitro and vascular development in vivo. Mol Cell Biol. 30: 3620-3634
• Cueni L, Hegyi I, Shin J, Albinger-Hegy A, Gruber S, Kunstfeld R, Moch H, Detmar M. (2010) Tumor lymphangiogenesis and metastasis to lymph nodes induced by cancer cell expression of podoplanin. Am J Pathol, 177: 1004-16
• Kang J, Yoo J, Lee S, Tang W, Aguilar B, Ramu S, Choi I, Otu H, Shin J, Dotto P, Koh Ch, Detmar M., Hong YK. (2010) An exquisite cross-control mechanism among endothelial cell fate regulators directs the plasticity and heterogeneity of lymphatic endothelial cells. Blood, 116: 140-50.
• Van de Veire S, Stalmans I, Heindryckx F, Oura H, Tijeras-Raballand A, Schmidt T, Loges S, Albrecht I, Jonckx B, Vinckier S, Van Steenkiste C, Tugues S, Rolny C, De Mol M, Dettori D, Hainaud P, Coenegrachts L, Contreres JO, Van Bergen T, Cuervo H, Xiao WH, Le Henaff C, Buysschaert I, Kharabi Masouleh B, Geerts A, Schomber T, Bonnin P, Lambert V, Haustraete J, Zacchigna S, Rakic JM, Jiménez W, Noël A, Giacca M, Colle I, Foidart JM, Tobelem G, Morales-Ruiz M, Vilar J, Maxwell P, Vinores SA, Carmeliet G, Dewerchin M, Claesson-Welsh L, Dupuy E, Van Vlierberghe H, Christofori G, Mazzone M, Detmar M, Collen D, Carmeliet P. (2010) Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease. Cell, 141: 178-90.
• Jurisic G, Sundberg JP, Bleich A, Leiter EH, Broman KW, Buechler G, Alley L, Vestweber D, Detmar M. (2010) Quantitative lymphatic vessel trait analysis suggests Vcam1 as candidate modifier gene of inflammatory bowel disease. Genes Immun, 11: 219-31
• Kajiya K., Detmar M. (2010) The role of angiogenesis and lymphangiogenesis in UVB-induced skin damage and skin aging. In: Rhein LD, Fluhr JW (eds), Aging Skin: current and future therapeutic strategies. Allured Books, 99-110

2009

• Schonthaler HB, Huggenberger R, Wculek SK, Detmar M, Wagner EF. (2009) Systemic anti-VEGF treatment strongly reduces skin inflammation in a mouse model of psoriasis. Proc Natl Acad Sci (USA), 15; 106: 21264-9
• Mumprecht V, Detmar M. (2009) Lymphangiogenesis and Cancer Metastasis. J Cell Mol Med, 13: 1405-16
• Hirakawa S, Detmar M, Kerjaschki D, Nagamatsu S, Matsuo K, Tanemura A, Kamata N, Higashikawa K, Okazaki H, Kameda K, Fukuda H, Mori H, Hanakawa Y, Sayama K, Shirakata Y, Tohyama M, Tokumaru S, Katayama I, Hashimoto K. (2009) Nodal Lymphangiogenesis and Metastasis: Role of Tumor-induced Lymphatic Vessel Activation in Extramammary Paget’s Disease. Am J Pathol, 175: 2235-2248
• Kaelin R, Tobler NE, Detmar M, Brändli AW. (2009) An in vivo chemical library screen in Xenopus tadpoles reveals novel pathways involved in angiogenesis and lymphangiogenesis. Blood, 114: 1110-22
• Cueni LN, Detmar M. (2009) Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions. Exp Cell Res, 315: 1715-23
• Velasco P, Huegel R, Brasch J, Schröder JM, Weichenthal M, Stockfleth E, Schwarz T, Lawler J, Detmar M, Lange-Asschenfeldt B. (2009) The Angiogenesis Inhibitor Thrombospondin-1 Inhibits Acute Cutaneous Hypersensitivity Reactions. J Invest Dermatol, 129: 2022-30
• Kajiya K, Sawane M, Huggenberger R, Detmar M. (2009) Activation of the VEGFR-3 pathway by VEGF-C attenuates UVB-induced edema formation and skin inflammation by promoting lymphangiogenesis. J Invest Dermatol, 129: 1292-8.
• Vigl B, Zgraggen C, Rehman N., Bänziger-Tobler NE, Detmar M., Halin C. (2009) Coxsackie-and adenovirus receptor (CAR) is expressed in lymphatic vessels in human skin and affects lymphatic endothelial cell function in vitro. Exp Cell Res, 315: 336-47
• Schulz MMP, Gebäck T, Koumoutsakos P, Detmar M. (2009) TScratch: A novel and simple software tool for automated analysis of monolayer wound healing assays. BioTechniques, 46: 265-274
• Jurisic G, Detmar M. (2009) Lymphatic endothelium in health and disease. Cell Tissue Res, 335: 97-108
• Doeden K, Ma Z, Narasimhan B, Swetter SM, Detmar M, Dadras SS. (2009) Lymphatic invasion in cutaneous melanoma is associated with sentinel lymph node metastasis. J Cutan Pathol, 36: 772-80.
• Rinderknecht M, Detmar M. Molecular mechanisms of lymph node metastasis. (2009) In: Stacker S, Achen M (Eds). Lymphangiogenesis in cancer metastasis. Springer, Vol 13: 55-82
• Detmar M. Tumor and lymph node lymphangiogenesis. (2009) In: Stanley Leong (Ed.) From Local Invasion to Metastatic Cancer. Involvement of Distant Sites Through the Lymphovascular System. Series: Current Clinical Oncology, Springer, 255-262

2008

• Shin J, Huggenberger R, Detmar M. (2008) Transcriptional profiling of VEGF-A and VEGF-C target genes in lymphatic endothelium reveals endothelial-specific molecule-1 as a novel mediator of lymphangiogenesis. Blood 112: 2318-2326
• Bänziger-Tobler NE, Halin C, Kajiya K, Detmar M., Growth hormone promotes lymphangiogenesis. Am J. Pathol. 173: 586-597
• Halin C., Fahrngruber H., Meingassner J.G., Bold G., Littlewood Evans A., Stuetz A., Detmar M. (2008) Inhibition of chronic and acute skin inflammation by treatment with a VEGF receptor tyrosine kinase inhibitor. Am. J. Pathol. 173: 265-77
• Dadras SS., Skrzypek A., Nguyen L., Shin J., Schulz MMP., Arbiser J., Mihm MC., Detmar M. Prox-1 promotes invasion of kaposiform hemangioendotheliomas. J. Invest Derm. 128: 2798-806
• Shin JW, Jurisic G, Detmar M. (2008) Lymphatic-specific expression of dipeptidyl peptidase IV and its dual role in lymphatic endothelial function. Exp Cell Res, 314: 3048-3056
• Stanczyk J., Leslie D.M., Brentano F., Sanchez-Pernaute O., Kolling Ch., Gay R.E., Detmar M., Gay S., Kyburz D. (2008) Altered expression of microRNAs in the synovial tissue and synovial fibroblasts in rheumatoid arthritis. Arthritis Rheum. 58: 1001-1009
• Halin C., Detmar M. Inflammation, angiogenesis and lymphangiogenesis. Methods Enzymol, 445: 1-25
• Rinderknecht M, Detmar M. (2008) Tumor lymphangiogenesis and melanoma metastasis. J Cell Physiol, 216: 347-354
• Cueni L., Detmar M., The lymphatic system in health and disease. Lymphat Res Biol, 6: 109-22
• Cueni L., Detmar M. (2008) Lymphatic vascular system and lymphangiogenesis. In: Angiogenesis: an integrative approach from science to medicine. Ed. Figg W. and Folkman J., Springer; 43: 505-516

2007

• Kajiya K., Huggenberger R., Drinnenberg I., Ma B., Detmar M. (2007) Nitric oxide mediates lymphatic vessel activation via soluble guanylate cyclase a1b1 - impact on inflammation. FASEB, 22:530-7
• Roesli Ch., Mumprecht V., Neri D., Detmar M. (2007) Identification of the surface-accessible, lineage-specific vascular proteome by two-dimensional peptide mapping. FASEB, 22: 1933-44
• Hirakawa S., Brown LF., Kodama S., Paavonen K., Alitalo K., Detmar M. (2007) VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites. Blood, 109: 1010-7
• Halin C., Tobler N E., Vigl B., Brown LF., Detmar M. (2007) VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes. Blood, 110: 3158-67
• Kajiya K., Kunstfeld R., Chung J.H., Detmar M., (2007) Reduction of lymphatic vessels in photodamaged human skin. J Derm Science 47: 241-3
• Trachsel E., Kaspar M., Bootz F., Detmar M., Neri, D. (2007) A human monoclonal antibody specific to oncofetal fibronectin selectively targets chronic skin inflammation in vivo. J Invest Dermatol, 127: 881-6
• Liersch R., Detmar M. (2007) Lymphangiogenesis in development and disease. Thromb Haemostasis, 98: 304-10
• Zehnder-Fjällmann AH, Marty C., Halin C., Hohn A., Schibli R., Ballmer-Hofer K., Schwendener RA. (2007) Evaluation of anti-VEGFR-3 specific scFv antibodies as potential therapeutic and diagnostic tools for tumor lymph-angiogenesis. Oncol Rep.18: 933-41.
• Shin J., Detmar M. (2007) Angiogenesis and lymphangiogenesis in cutaneous cancer. Exp Dermatol, 16: 865-866

2006

• Liersch R., Nay F., Lu L., Detmar M. (2006) Induction of lymphatic endothelial cell differentiation in embryoid bodies. Blood, 107:1214-6
• Halin C., Detmar M. (2006) An unexpected connection: lymph node lymphangiogenesis and dendritic cell migration. Immunity, 24:129-31.
• Kajiya K., Hirakawa S., Detmar M. (2006) Vascular endothelial growth factor-A mediates ultraviolet B-induced impairment of lymphatic vessel function. Am J Pathol, 169: 1496-503
• Shin JW., Min M., Larrieu-Lahargue F., Canron X., Kunstfeld R., Nguyen L., Henderson JE., Bikfalvi A., Detmar M., Hong YK. (2006) Prox1 promotes lineage-specific expression of FGF receptor-3 in lymphatic endothelium: A role for FGF signaling in lymphangio-genesis. Mol Biol Cell., 17:576-84.
• Kajiya K., Detmar M. (2006) An important role of lymphatic vessels in the control of UVB-induced edema formation and inflammation. J Invest Dermatol, 126:919-21
• Young HS., Summers AM., Read I., Fairhurst DA., Plant D., Campalani E., Francis D., Smith C., Barker JNWN., Detmar M., Brenchley PEC., Griffiths CEM. (2006) Interaction between genetic control of vascular endothelial growth factor production and retinoid responsiveness in psoriasis. J Invest Dermatol, 126:453-9.
• Cueni L., Detmar M. (2006) New insights into the molecular control of the lymphatic vascular system and its role in disease. J Invest Dermatol, 126: 2167-77
• Tobler N., Detmar M. (2006) Tumor and lymph node lymphangiogenesis - impact on cancer metastasis. J Leukocyte Biology, 80: 691-6
• Wissmann Ch., Detmar M. (2006) Pathways targeting tumor lymphangiogenesis. Clin Cancer Res, 12: 6865-8.
• Hirakawa S., Matsuda K.M., Detmar M. (2006) Multiple uses of animal models in cancer metastasis. In: Molecular biology of cancer development and angiogenesis. Ed. Masabumi Shibuya, University of Tokyo, Japan.

2005

• Hirakawa S., Kodama, S., Kunstfeld R., Kajiya K., Brown LF., Detmar M. (2005) VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. J Exp Med, 201: 1089-99
• Kajiya K., Hirakawa H., Ma B., Drinnenberg I., Detmar M. (2005) Hepatocyte growth factor promotes lymphatic vessel formation and function. EMBO J, 24: 2885-95
• Hirakawa S., Fujii S., Kajiya K Yano K., Detmar M. (2005) Vascular endothelial growth factor promotes sensitivity to ultraviolet-B-induced cutaneous photodamage. Blood, 105: 2392-9
• Schacht V., Dadras SS., Johnson LA., Jackson DG., Hong YK., Detmar M. (2005) Upregulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol, 166: 913-21
• Dadras SS., Lange-Asschenfeldt B., Velasco P., Nguyen L., Vora A., Muzikansky A., Mihm MC., Detmar M. (2005) Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes. Mod Pathol, 18: 1232-42
• Yano K., Kadoya K., Kajiya K., Hong YK., Detmar M. (2005) Ultraviolet B irradiation of human skin induces an angiogenic switch that is mediated by upregulation of vascular endothelial growth factor and by downregulation of thrombospondin-1. Br J Dermatology 152: 115-121
• Mamluk R., Klagsbrun M., Detmar M., Bielenberg DR. (2005) Soluble neuropilin targeted to the skin inhibits vascular permeability. Angiogenesis. 8: 217-27.