1997-1999

1999

• Goswami N., Higginbotham C., Volkert W., Alberto R., Nef W., Jurisson, S. Rhodium-105 tetrathioether complexes: Radiochemistry and initial biological evaluation. Nucl. Med. Biol. 26, 951-957 (1999).

• Ametamey S.M., Samnick S., Leenders K.L., Vontobel P., Quack G., Parsons C.G., Schubiger P.A. Fluorine-18 radiolabelling, biodistribution studies and preliminary PET evaluation of a new memantine derivative for imaging the NMDA receptor. J. Recept. Signal Trans. Res., 19, 129-141 (1999).

• Schibli R., Katti K.V., Higginbotham C., Volkert W.A., Alberto R. In vitro and in vivo evaluation of bidentate, water-soluble phosphine ligands as anchor groups for the organometallic fac- Tc-99m(CO)(3) (+)-core. Nucl. Med. Biol. 26, 711-716 (1999).

• Alberto R., Schibli R., Schubiger P.A., Abram U., Pietzsch H.J., Johannson B. First application of fac-[99mTc(OH2)3(CO)3]+ in bioorganometallic chemistry: Design, structure, and in vitro affinity of a 5-HT1A receptor ligand labeled with 99mTc. J. Am. Chem. Soc., 121, 6076-6077 (1999).

• Patt J.T., Spang J.E., Westera G., Buck A., Schubiger P.A. Synthesis and in vivo studies of [11C]N-methyl-epibatidine: Comparison of the stereoisomers. Nucl. Med. Biol., 26, 165-173 (1999).

• Spang J.E., Patt J.T.W., Bertrand S., Bertrand D., Westera G., Schubiger P.A. Synthesis and electrophysiological studies of a novel epibatidine analogue. J. Recept. Signal Trans. Res., 19, 521-531 (1999).

• Volkert W.A., Karra S.R., Gali H., Schibli R., Katti K.V. Bifunctional chelation systems based on hydroxymethyl phosphine-based donor groups. Phosphorus Sulfur and Silicon and the Related Elements, 146, 489-492 (1999).

• Bertrand S., Patt J.T., Spang J.E., Westera G., Bertrand, D., Schubiger P.A. Neuronal nAChRs stereoselective to non-natural epibatidine derivatives. FEBS Lett. 450, 273-279 (1999).

• Alberto R., Angst D., Abram U., Ortner K., Kaden T.A., Schubiger P.A. Unexpected polymeric string formation between Ag(I) and a homoleptic thioether cage: Synthesis and crystal structure of [R,R'-S6tricosane] and {[Ag(R,R'-S6hexacosane)(tos)]}¥. Chem. Commun., 16, 1513-1514 (1999).

• Waibel R., Alberto R., Willuda J., Finnern R., Schibli R., Stichelberger A., Egli A., Abram U., Mach J.-P., Plückthun A., Schubiger P.A. Stable one-step technetium -99m labeling of his-tagged recombinant proteins with a novel Tc-carbonyl complex. Nat. Biotechnol., 17, 897-901 (1999).

• Ryser J.-E., Bläuenstein P., Rémy N., Weinreich R., Hasler P.H., Novak-Hofer I., Schubiger P.A. [76Br]Bromodeoxyuridine, a potential tracer for the measurement of cell proliferation by positron emission tomography, in vitro and in vivo studies in mice. Nucl. Med. Biol., 26, 673-679 (1999).

• Zessin J., Gucker P., Ametamey S.M., Steinbach J., Brust P., Vollenweider F.X., Johannsen B., Schubiger P.A. Efficient synthesis of enantiomerically pure thioster precursors of [11C]McN-5652 from racemic McN-5652. J. Lab. Comp. Radiopharm., 42, 1301-1312 (1999).

• Spang J.E., Patt J.T., Westera G., Schubiger P.A. Synthesis and [11C]-radiolabelling of dechloro-epibatidine and 2PABH, two potential radioligands for studying the central nAChRs in vivo. J. Lab. Comp. Radiopharm., 42, 761-771 (1999).

• Schönbächler R., Ametamey S.M., Schubiger P.A. Synthesis and 11C-radiolabelling of a tropane derivative lacking the 2b ester group: a potential PET-tracer for the dopamine transporter. J. Lab. Comp. Radiopharm., 42, 447-456 (1999).

• Schubiger P.A., Allemann-Tannahill L., Egli A., Schibli R., Alberto R., Carrel-Rémy N., Willmann M., Bläuenstein P., Tourwé D. Catabolism of neurotensins Implications for the design of radiolabeling strategies of peptides. Quarterly J. Nucl. Med., 43, 155-158 (1999).

• Meli M.L., Carrel F., Waibel R., Amstutz H., Crompton N., Jaussi R., Moch H., Schubiger P.A., Novak-Hofer I. Anti-neuroblastoma antibody chCE7 binds to an isoform of L1-CAM present in renal carcinoma cells. Int. J. Cancer, 83, 401-408 (1999).

• Zimmermann K., Gianollini S., Schubiger P.A., Novak-Hofer I. A triglycine linker improves tumor uptake and biodistributions of 67-Cu-labeled anti-neuroblastoma MAB chCE7 F(ab')2 fragments. Nucl. Med. Biol., 26, 943-950 (1999).

• Egli A., Alberto R., Tannahill L., Schibli R., Abram U., Schaffland A., Waibel R., Tourwé D., Jeannin L., Iterbeke K., Schubiger P.A. Organometallic 99mTc-aquaion labels peptide to an unprecedented high specific activity. J. Nucl. Med., 40, 1913-1917 (1999).

• Willuda J., Honegger  A., Waibel R., Schubiger P.A., Stahel R., Zwangemeister-Wittke U., Plückthun A. High thermal stability is essential for tumor targeting of antibody fragments: Engineering of a humanized anti-epithelial glycoprotein-2 (Epithelial cell adhesion molecule) single-chain Fv fragment. Cancer Res., 59, 5758-5767 (1999).

• Boeni R., Bläuenstein P., Dummer R., von Schulthess G.K., Schubiger P.A., Steinert H.C. Non-invasive assessment of tumor cell proliferation with positron emission tomography and [76Br]bromodeoxyuridine. Melanoma Res., 9, 569-573 (1999).

• Osbourn, J.K., McCafferty, J., Derbyshire, E.J., Waibel, R., Chester, K., Boxer, G., Allen, D. Isolation of a panel of human anti-CEA single chain Fv from a large phage display library. Tumor Targeting, 4, 150-157 (1999).

1998

• Bläuenstein P., Rémy N., Buck A., Ametamey S., Häberli M., Schubiger P.A. In vivo properties of N-(2-aminoethyl-5-halogeno-2-pyridinecarboxamide 18F- and 123I-labelled reversible inhibitors of monoamine oxidase B. Nucl. Med. Biol., 25, 47-52 (1998).

• Samnick S., Ametamey S., Leenders K.L., Vontobel P., Quack G., Parsons C.G., Neu H., Schubiger P.A. Electrophysiological study, biodistribution in Mice and Preliminary PET Evaluation in a Rhesus Monkey of 1-amino-3-[18F]fluoromethyl-5-methyl-adamantane (18F-MEM): A potential radioligand for mapping the NMDA-receptor complex. Nucl. Med. Biol., 25, 323-330 (1998).

• Samnick S., Remy N., Ametamey S., Bader J.B., Brandau W., Kirsch C.M. 123-MSP and F C-11 MSP: New selective 5-HT2A receptor radiopharmaceuticals for in vivo studies of neuronal 5-HT2 serotonin receptors. Synthesis, in vitro binding study with unlabelled analogues and preliminary in vivo evaluation in mice. Life Science, 63, 2001-2013 (1998).

• Hoepping A., Reisgys M., Brust P., Seifert S., Spies H., Alberto R., Johannsen B. TROTEC-1: A new high-affinity ligand for labeling of the dopamine transporter. J. Med. Chem. 41, 4429-4432 (1998).

• Ametamey S., Vollenweider F.X., Patt J., Bourquin D., Hasler F., Beer H.-F., Schubiger P.A. 11C-Radiolabeling of hallucinogenic psilocin, a potential radioligand for studying the role of serotonin receptors in psychotic symptom formation. J. Lab. Comp. Radiopharm., 41, 585-594 (1998).

• Alberto R., Schibli R., Egli A., Abram U., Abram S., Kaden T.A., Schubiger P.A. Steps towards [(C5Me5)TcO3]: Novel synthesis of [(C5Me5)TcO3] from [{Tc(m3-OH)(CO)3}4] and oxidation of [([(C5Me5)M(CO)3] (M=Tc, Re) with Br2. Polyhedron, 17, 1133-1140 (1998).

• Buck A., Frey L.D., Bläuenstein P., Krämer G., Siegel A., Weber B., Schubiger P.A., Wieser H.G. Monoamine oxidase B single-photon emission tomography with [123I]Ro 43-0463: imaging in volunteers and patients with temporal lobe epilepsy. Eur. J. Nucl. Med., 25, 464-470 (1998).

• Alberto R., Schibli R., Egli A., Schubiger P.A., Abram U., Kaden T.A. A Novel Organometallic aqua complex of technetium for the labeling of biomolecules: Synthesis of [99mTc(OH2)3(CO)3]+ from [99mTcO4]- in aqueous solution and its reaction with a bifunctional ligand. J. Am. Chem. Soc., 120, 7987-7988 (1998).

• Schibli R., Alberto R., Abram U., Abram S., Egli A., Schubiger P.A., Kaden T.A. Structural and 99Tc NNR investigations of complexes with fac-[Tc(CO)3]+ moieties and macrocyclic thioethers of various ring sizes: Synthesis and X-ray structure of the complexes fac-[Tc(9-ane-S3)(CO)3]Br, fac-[Tc2(tosylate)2(18-ane-S6)(CO)6], and fac-[Tc2(20-ane-S6-OH)(CO)6][tosylate]2. Inorg. Chem., 37, 3509-3516 (1998).

• Kramer A., Alberto R., Egli A., Novak-Hofer I., Hegetschweiler K., Abram U., Bernhardt P.V., Schubiger P.A. Derivatives of 1,3,5-triamino-1,3,5-trideoxy-cis-inositol as versatile pentadentate ligands for protein labeling with Re-186/188. prelabeling, biodistribution, and X-ray structural studies. Bioconjug. Chem., 9, 691-702 (1998).

• Abram U., Abram S., Schibli R., Alberto R., Dilworth J.R. Synthesis and structure of technetium(I) complexes with bis(diphenyl-thiophosphoryl)amide, {M(CO)3[Ph2PS)2N] (CH3CN)} (M=Tc, Re). Polyhedron, 17, 1303-1309 (1998).

• Alberto R., Schibli R., Waibel R., Abram U., Schubiger A.P. Basic aqueous chemistry of M(OH2)(3)(CO)(3) (+) (M = Re, Tc) directed towards radiopharmaceutical application. Coord. Chem Rev., 192, 901-919 (1999).

• Abram U., Alberto R., Dilworth J.R., Zheng Y.F., Ortner K. Rhenium and technetium complexes with diphenyl(2-pyridyl)phosphine. Polyhedron, 18, 2995-3003 (1999).

• Schibli R., Katti K.V., Volkert W.A., Barnes C.L. Novel coordination behavior of fac-[ReBr3(CO)3]2- with 1,3,5-triaza-7-phosphaadamantane (PTA). Systematic investigation on stepwise replacement of the halides by PTA ligand. Phase transfer studies and X-ray crystal structure of [Net4][ReBr2((PTA)(CO)3], [ReBr(PTA)2(CO)3] and [Re(PTA)3(CO)3]PF6. Inorg. Chem., 37, 5306-5312 (1998).

1997

• Novak-Hofer I., Zimmermann K., Maecke H.R., Amstutz H.P., Carrel F., Schubiger P.A. Tumor uptake and metabolism of copper-67-labeled monoclonal antibody chCE7 in nude mice bearing neuroblastoma xenografts. J. Nucl. Med., 38, 536-544 (1997).

• Hughes O.D.M., Bishop M.C., Perkins A.C., Frier M., Price M.R., Denton G., Smith A., Rutherford R.A.D., Schubiger P.A. Preclinical evaluation of 67Cu-labelled anti- mucin antibody C595 for therapeutic use in bladder cancer. Eur. J. Nucl. Med., 24, 439-443 (1997).

• Bischof Delaloye A., Delaloye B., Buchegger F., Vogel Ch.-A., Gillet M., Mach J.-P., Smith A., Schubiger P.A. Comparison of copper-67- and iodine-125-labeled anti-CEA monoclonal antibody biodistsribution in patients with colorectal tumors. J. Nucl. Med., 38, 847-853 (1997).

• Samnick S., Ametamey S., Gold M.R., Schubiger P.A. Synthesis and preliminary in vitro evaluation of a new memantine derivative 1-amino-3-[18F]fluoromethyl-5-methyl-adamantane: A potential ligand for mapping the N-methyl-D-asparate receptor complex, J. Lab. Comp. Radiopharm., 39, 241-250 (1997).

• Bläuenstein P., Pellikka R., Schubiger P.A. Reinvestigaton of a physiological eluate of the 52Fe/52mMn generator. Appl. Radiat. Isot., 48, 1097-1101 (1997).

• Rutherford R.A.D., Smith A., Waibel R., Schubiger P.A. Differential Inhibitory effect of L-lysine on renal accumulation of 67Cu-labelled F (ab’)2 fragments in mice. Int. J. Cancer, 72, 522-529 (1997).

• Carrel F., Amstutz H., Novak-Hofer I., Schubiger P.A. Evaluation of radioiodinated and radiocopper labeled monovalent fragments of monoclonal antibody chCE7 for targeting of neuroblastoma. Nucl. Med. Biol., 24, 539-546 (1997).

• Egli A., Hegetschweiler K., Alberto R., Abram U., Schibli R., Hedinger R., Gramlich V., Kissner R., Schubiger P.A. Hydrolysis of the organometallic aqua ion fac-triaquatri-carbonylrhenium (I). mechanism, pKa,, and formation constants of the polynuclear hydrolysis products. J. Organomet. Chem., 16, 1833-1840 (1997).

• Reisgys M., Wüst F., Alberto R., Schibli R., Schubiger P.A., Pietzsch H.-J., Spies H., Johannsen B. Synthesis of rhenium(I) and technetium(I) carbonyl/dithioether ligand complexes bearing 3,17b-estradiol. Bioorg. Med. Chem. Lett., 7, 2243-2246 (1997).

• Alberto R., Schibli R., Angst D., Schubiger P.A. Application of technetium and rhenium carbonyl chemistry to nuclear medicine. Preparation of [NEt4]2[TcCl3(CO)3] from [NBU4][TcO4] and structure of [NEt4][Tc2(m-Cl)3(CO)6]; structure of the model complexes [NEt4][Re2(m-OEt)2(m-OAc)(CO)6] and [ReBr({-CH2S(CH2)2Cl}2)(CO)3]. Trans. Met. Chem., 22, 597-601 (1997).

• Alberto R., Schibli R., Egli A., Knapp F.F., Schubiger P.A. Potential of the „[M(CO)3]+“ (M = Re, Tc) moiety for the labeling of biomolecules. Radiochimica Acta, 79, 99-103 (1997).