2005-2010

2010

• Zhernosekov, K., S. Lehenberger, U. Koster, H. Dorrer, A. Hohn, R. Schibli, and A. Turler, The low-energy beta(-) and electron emitter Tb-161 as alternative for Lu-177 for targeted radionuclides therapy. Nuclear Medicine and Biology, 2010, 37, 718-719.

• Zahnd, C., M. Kawe, M.T. Stumpp, C. de Pasquale, R. Tamaskovic, G. Nagy-Davidescu, B. Dreier, R. Schibli, H.K. Binz, R. Waibel, and A. Pluckthun, Efficient Tumor Targeting with High-Affinity Designed Ankyrin Repeat Proteins: Effects of Affinity and Molecular Size. Cancer Research, 2010, 70, 1595-1605.

• Struthers, H., D. Viertl, M. Kosinski, B. Spingler, F. Buchegger, and R. Schibli, Charge Dependent Substrate Activity of C3 ' and N3 Functionalized, Organometallic Technetium and Rhenium-Labeled Thymidine Derivatives toward Human Thymidine Kinase 1. Bioconjugate Chemistry, 2010, 21, 622-634.

• Struthers, H., T.L. Mindt, and R. Schibli, Metal chelating systems synthesized using the copper(I) catalyzed azide-alkyne cycloaddition. Dalton Transactions, 2010, 39, 675-696.

• Ross, T.L., M. Honer, C. Müller, V. Groehn, R. Schibli, and S.M. Ametamey, A New F-18-Labeled Folic Acid Derivative with Improved Properties for the PET Imaging of Folate Receptor Positive Tumors. Journal of Nuclear Medicine, 2010, 51, 1756-1762.

• Peckl-Schmid, D., S. Wolkerstorfer, S. Konigsberger, G. Achatz-Straussberger, S. Feichtner, E. Schwaiger, N. Zaborsky, M. Huemer, I.K. Gratz, R. Schibli, M. Lamers, R. Crameri, K. Moser, E.O. Luger, and G. Achatz, HAX1 deficiency: Impact on lymphopoiesis and B-cell development. European Journal of Immunology, 2010, 40, 3161-3172.

• Mumprecht, V., M. Honer, B. Vigl, S.T. Proulx, E. Trachsel, M. Kaspar, N.E. Banziger-Tobler, R. Schibli, D. Neri, and M. Detmar, In vivo Imaging of Inflammation- and Tumor-Induced Lymph Node Lymphangiogenesis by Immuno-Positron Emission Tomography. Cancer Research, 2010, 70, 8842-8851.

• Müller, C., J.A. Reddy, C.P. Leamon, and R. Schibli, Effects of the Antifolates Pemetrexed and CB3717 on the Tissue Distribution of Tc-99m-EC20 in Xenografted and Syngeneic Tumor-Bearing Mice. Molecular Pharmaceutics, 2010, 7, 597-604.

• Mindt, T.L., H. Struthers, B. Spingler, L. Brans, D. Tourwe, E. Garcia-Garayoa, and R. Schibli, Molecular Assembly of Multifunctional Tc-99m Radiopharmaceuticals Using "Clickable" Amino Acid Derivatives. ChemMedChem, 2010, 5, 2026-2038.

• Jeger, S., K. Zimmermann, A. Blanc, J. Grunberg, M. Honer, P. Hunziker, H. Struthers, and R. Schibli, Site-Specific and Stoichiometric Modification of Antibodies by Bacterial Transglutaminase. Angewandte Chemie-International Edition, 2010, 49, 9995-9997.

• Hueting, R., M. Christlieb, J.R. Dilworth, E.G. Garayoa, V. Gouverneur, M.W. Jones, V. Maes, R. Schibli, X. Sun, and D.A. Tourwe, Bis(thiosemicarbazones) as bifunctional chelators for the room temperature 64-copper labeling of peptides. Dalton Transactions, 2010, 39, 3620-3632.

• Garayoa, E.G., S. Daepp, L. Brans, V. Maes, A. Blanc, O. Gasser, D. Tourwe, and R. Schibli, Improved Tumor Imaging and Therapy with Radiolabeled PEGylated Bombesin Analogues. Journal of Peptide Science, 2010, 16, 186-186.

2009

• M. Honer, T. Ebenhan, S. M. Ametamey, P. A. Schubiger, M. Becquet, S. Ferretti, C. Cannet, M. Rausch and P. M. J. McSheehy “Comparison of [18F]-tracers in various experimental tumour models by PET imaging and identification of an early response biomarker for the novel microtubule stabiliser patupilone” Molecular Imaging & Biology, 11, 308-321 (2009).

• A. Höhne, L. Yu, L. Mu, M. Reiher, U. Voigtmann, U. Klar, K. Graham, P. A. Schubiger, S. M. Ametamey „Organnofluorosilanes as model compounds for 18F-labeled silicon-based PET tracers and their hydrolytic stability-experimental data and theoretical calculations„ Chemistry-A European Journal 15, 3736-3743 (2009).

• F. Hasler, O.F. Kuznetsova, R. N. Krasikova, T. Cservenyak, B.B. Quedow, F. X. Vollenweider, S. M. Ametamey, G. Westera “GMP-compliant synthesis of 18F-Altanserin and human plasma metabolic studies” J. Applied Radiation and Isotopes, 67, 598-601 (2009).

• C. Lucatelli, M. Honer, T. Ross, J. -F. Salazar, P. A. Schubiger, S. M. Ametamey “Synthesis, radiolabeling, in vitro and in vivo evaluation of 18F-PECMO as a PET ligand for imaging metabotropic glutamate receptor subtype 5” Nucl. Med. Biology, 36, 613-622 (2009).

• U. Roehn, J. Becaud, L. Mu, A. Srinivan, T. Stellfeld, A. Fitzner, K. Graham, L. Dinkelborg, P. A. Schubiger, S. M. Ametamey “Nucleophilic ring-opening of activated aziridines: A one-step method for labelling biomolecules with fluorine-18” J Fluorine Chem. 130, 902-912 (2009).

• D. Frank, H. Nann, P. Davi, P. A. Schubiger, S. M. Ametamey „Faster analysis of radiopharmaceuticals using UPLC in combination with volume radio flow cell“ Applied Radiation and Isotopes 67, 1068-1070 (2009).

• J. Becaud, L. Mu, M. Karramkam, P. A. Schubiger, S. M. Ametamey, K. Graham, T. Stellfed, L. Lehmann, S. Borkowski, D. Berndorff, L. Dinkelborg, A. Srinivasan, R. Smits, B. Koksch “Direct one-step fluorine-18 labeling of peptides via nucleophilic aromatic substitution” Bioconjugate Chemistry (in press).

2008

• L. Mu, A. Höhne, P. A. Schubiger, S. M. Ametamey, K. Graham, T. Stellfeld, S. Borkowski, D. Berndorf, U. Klar, U. Voigmann, J. E. Cyr, M. Friebe, L. Dinkelborg, A. Srinivasan Silicon-based building blocks for one-step F-18-radiolabeling of peptides for PET imaging Ang. Chem-Int 47, (26) 4922-4925 (2008).

• V. Treyer, J. Streffer, S. M. Ametamey, A. Bettio, P. Bläuenstein, M. Schmidt, F. Gasparini, U. Fischer, C. Hock, A. Buck „Radiation dosimetry and biodistribution of 11C- ABP688 measured in healthy volunteers“ Eur. J. Nucl. Med & Mol. Imaging 35, (4) 766-770 (2008).

• S. M. Ametamey, M. Honer, P. A. Schubiger “Molecular imaging with PET” Chem Rev. 108(5), 1501-1516 (2008).

• Höhne, L. Mu, M. Honer, P.A. Schubiger, S. M. Ametamey, K. Graham, T. Stellfeld, S. Borkowski, D. Berndorf, U. Klar, U. Voigmann, J. E. Cyr, M. Friebe, L. Dinkelborg, A. Srinivasan “ Synthesis, 18F-labeling, and in vitro and in vivo studies of bombesin peptides modified with silicon-based building blocks” Bioconjugate Chemistry 19, 1871-1879 (2008).

• M. Honer, T. Ebenhan, S. M. Ametamey, P. A. Schubiger, M. Becquet, S. Ferretti, C. Cannet, M. Rausch and P. M. J. McSheehy “Comparison of [18F]-tracers in various experimental tumour models by PET imaging and identification of an early response biomarker for the novel microtubule stabiliser patupilone” Molecular Imaging & Biology, 11, 308-321 (2009).

• T. L. Ross, Michael Honer, P. Y. H. Lam, T. L. Mindt, V. Groehn, R. Schibli, P. A. Schubiger, S. M. Ametamey “Fluorine-18 Click Radiosynthesis and Preclinical Evaluation of a New ¹⁸F-Labelled Folic Acid Derivative” Bioconjugate Chemistry 19, 2462-2470 (2008).
  
  
• Sturthers H.R., Hagenbach A., Abram U., Schibli R.* (2008) Organometallic Re(CO)₃- and Re(CO)₂(NO)-labeled substrates for human thymidine kinase 1: A side by side comparison, Inorg. Chem., submitted.
  
  
• Friedli A., Novak-Hofer I., Cohrs S., Ballmer-Hofer K., Schubiger P. A., Schibli R., Grünberg J.* (2008) Anti-L1 cell adhesion molecule antibodies inactivate integrins on SKOV3ip human ovarian carcinoma cells in vitro and inhibit sL1-induced angiogenesis in vivo, Int. J. Cancer, submitted.
  
  
• Mindt T.L., Schweinsberg C., Brans L., Hagenbach A., Abram U., Tourwé D. A., García-Garayoa E., Schibli R.* (2008) A Click Approach to Structurally Diverse Conjugates Containing a Central Di-1,2,3-Triazole Metal Chelate, ChemMedChem, accepted.
  
  
• Sparr C., Michel M., Marti R.E., Müller C., Schibli R., Moser R., Groehn V. * (2008) Synthesis of a Novel (g)-Folic Acid-N -Histidine-Conjugate Suitable for Labelling with ^99mTc and ¹⁸⁸Re. Synthesis, accepted.
  
  
• 5. Brans L., Maes V., García-Garayoa E., Schweinsberg C., Daepp S., Bläuenstein P., Schubiger P. A., Schibli R., Tourwé D. A.* (2008) Glycation methods for bombesin analogs containing the (N^aHis)Ac chelator for ^99mTc(CO)₃ radiolabeling, Chemical Biology & Drug Design, 72, 496.
  
  
• Desbouis D., Spiwok V., Struthers H., Küster T., Schibli R.* (2008) Synthesis, In Vitro and In Silico Evaluation of Organometallic Technetium and Rhenium Thymidine Complexes with Retained Substrate Activity Towards Human Thymidine Kinase Type 1, J. Med. Chem. 51, 6689.
  
  
• García-Garayoa E, Schweinsberg C., Maes V., Brans L., Bläuenstein P., Tourwé D. A., Schibli R., Schubiger P.A.* (2008) Influence of the Molecular Charge on the Biodistribution of Bombesin Analogues Labeled with the [^99mTc(CO)₃]-Core, Bioconjugate Chem., 19, 2409.
  
  
• Schweinsberg C., Maes V., Brans L., Bläuenstein P., Tourwé D. A., Schubiger P.A., Schibli R., García-Garayoa E.* (2008) Novel Glycated [^99mTc(CO)₃]-labeled Bombesin Analogues for Improved Targeting of Gastrin-Releasing Peptide Receptor-Positive Tumors, Bioconjugate Chem., 19, 2432.
  
  
• Mindt T.L., Müller C., Melis M., DeJong M., Schibli R.*. (2008) “Click-to-Chelate”: In Vitro and In Vivo Comparison of a ^99mTc(CO)₃-Labeled N(t)-Histidine Folate Derivative with Its Isostructural, Clicked 1,2,3-Triazole Analogue, Bioconjugate Chem., 19, 1689.
  
  
• Struthers H., Spingler B. Mindt T.L., Schibli R.* (2008) “Click-to-Chelate”: Design and Incorporation of Triazole Containing Metal Chelating Systems into Biomolecules of Diagnostic and Therapeutic Interest. Chemistry Eur. J., 14, 6173.
  
  
• Waibel R., Treichler H., Schaefer N.G., van Staveren D.R., Mundwiler S., Kunze S., Küenzi M., Alberto R., Nüesch J., Knuth A. Moch H., Schibli R., Schubiger P.A.* (2008) New derivatives of vitamin B₁₂ show preferential targeting of tumors. Cancer Res., 68, 2904.
  
  
• Mindt T. L., Jungi V., Friedli A., Pla G., Novak-Hofer I., Grünberg J. Schibli R.* (2008) Amino Acid Specific Modification of Antibodies by Transglutaminases. Bioconjugate Chem. 19, 271.
  
  
• Müller C., Forrer F., Schibli R., Krenning E.P., de Jong M.* (2008) SPECT Study of Folate Receptor-Positive Malignant and Normal Tissues in Mice Using a Novel ^99mTc-Radiofolate, J. Nucl. Med., 49, 310.
  
  
• Müller C., Schibli R., Krenning E.P., de Jong M.* (2008) Pemetrexed Improves Tumor Selectivity of ¹¹¹In-DTPA-Folate in Mice with Folate Receptor–Positive Ovarian Cancer. J. Nucl. Med., 49, 623.

2007

• K. Knogel, J. Grünberg, K. Zimmermann, S. Cohrs, M. Honer, S. M. Ametamey, P. Altevogt, M. Fogel, P. A. Schubiger, I. Novak-Hofer” Copper-67 radioimmunotherapy and growth inhibition by anti-L1 cell adhesion molecule monoclonal antibodies in a therapy model of ovarian cancer metastasis ” Clin. Cancer Res 13(2), 603-611, (2007).

• S. M. Ametamey, V. Treyer, J. Streffer, M. T. Wyss, M. Schmidt, M. Blagoev, S. Hintermann, Y. P. Auberson, F. Gasparini, U. Fischer, A.. Buck „ Human PET studies of metabotropic glutamate receptor subtype5 with [11C]-ABP688“ J. Nucl. Med. 48, 247-252, (2007).

• M. T. Wyss, S. M. Ametamey, V. Treyer, A. Bettio, M. Blagoev, L. J. Kessler, C. Burger, B. Weber, M. Schmidt, F. Gasparini, A. Buck “ Quantitative evaluation of ¹¹C-ABP688 as PET ligand for the measurement of the metabotropic glutamate receptor subtype 5 using autoradiographic studies and a beta-scintillator” NeuroImage, 35, 1086-1092 (2007).

• M. Honer, A. Stoffel, L.J. Kessler, P. A. Schubiger, S. M. Ametamey „Radiolabeling, in vitro and in vivo evaluation of [18F]-FE-DABP688 as a PET ligand for the metabotropic glutamate receptor subtype 5 Nucl. Med. Biology, 34, 973-980 (2007).

• V. Treyer, J. Streffer, M. T. Wyss, A. Bettio, S. M. Ametamey, U. Fischer, M. Schmidt, F. Gasparini, C. Hock, A. Buck „ Evaluation of the metabotropic glutamate receptor subtype5 using PET and [11C]-ABP688, assessment of methods“J. Nucl. Med. 48, 1207-1215, (2007).
  
  
• Stichelberger M., Desbouis D., Spiwok V., Scapozza L., Schubiger P.A., Schibli R.* (2007) Synthesis, in vitro and in silico assessment of organometallic Rhenium(I) and Technetium(I) thymidine complexes. J. Organomet. Chem. 692, 1255.
  
  
• Desbouis D., Schubiger P.A., Schibli R.* (2007) Synthesis of Tricarbonyl Rhenium and Technetium complexes of a 5'-carboxamide 5-Ethyl-2'-Deoxyuridine for Selective Inhibition of Herpes Simplex Virus Thymidine Kinase 1. J. Organomet. Chem., 692, 1340.
  
  
• Müller C., Schubiger P.A., Schibli R.* (2007) Isostructural Folate Conjugates Radiolabeled with the Matched Pair ^99mTc/¹⁸⁸Re: A Potential Strategy for Diagnosis and Therapy of Folate-Receptor Positive Tumors. Nucl. Med Biol., 34, 595.
  
  
• Müller C., Schibli R., Forrer F. Krenning EP, de Jong M.* (2007) Dose-Dependent Effects of (Anti)Folate Pre-Injection on ^99mTc-Radiofolate Uptake in Tumors and Kidneys. Nucl. Med Biol., 34, 603.
  
  
• Hohn A., Zimmermann K., Schaub E., Hirzel W., Schubiger P.A., Schibli R.* (2007) Production and Separation of ”Non-Standard” PET Nuclides at a Large Cyclotron Facility: The Experience at the Paul Scherrer Institute Switzerland. Q. J. Nucl. Med., 51, 1.
  
  
• Mindt T. L., Schibli R.* (2007) Cu(I)-catalyzed interamolecular cyclization of alkynoic acids in aqueous media – a “click side reaction”. J. Org. Chem., 72, 10247.
  
  
• Zehnder-Fjällmann A. H. M., Marty C., Halin C., Hohn A., Schibli R., Ballmer-Hofer K., Schwendener R. A.* (2007) Evaluation of anti-VEGFR-3 specific scFv antibodies as potential therapeutic and diagnostic tools for tumor lymph-angiogenesis. Oncology Reports 18, 933.

2006

• M. T. Wyss, M. Honer, P. A. Schubiger, S. M. Ametamey” NanoPET imaging of [18F]fluoromisonidazole in experimental mouse models” Eur. J. Nucl. Med. & Mol. Imaging 33, 311-318, (2006).

• S. M. Ametamey, L. J. Kessler, M. Honer, M. T. Wyss, A. Buck, S. Hintermann, Y. P. Auberson, F. Gasparini, P. A. Schubiger „ Radiosynthesis and preclinical evaluation of [11C]-ABP688 as a probe for imaging the metabotropic glutamate receptor subtype5 (mGluR5)“ J. Nucl. Med. 47, 698-705, (2006).

• O. Riesterer M. Honer, C. Oehler, S. M. Ametamey, M. Pruschy “Ionizing radiation antagonizes tumor hypoxia induced by anti.angiogenic treatment” Clin Cancer Res, 12, 3518-3524 (2006).

• S. M. Ametamey, P. A. Schubiger “PET pharmaceuticals for neuroreceptor imaging” Nucl. Sci. Technique, 17, 139-143, (2006).

• A. Johayem, S. Raic-Malic, K. Lazzati, P. A. Schubiger, L. Scapozza, S. M. Ametamey “Synthesis and chararcterization of a C (6) nucleoside analogue for the imaging of the gene expression of Herpes Simplex Virus Type-1 Thymidine kinase (HSV1 TK)” Chemistry & Diversity, 3, 274-283 (2006).

• C. M. Matter, M. T. Wyss, P. Meier. N. Spath, T. von Lukowcz, C. Lohmann B. Weber, A. R. de Molina. J. C. Lacal, S. M. Ametamey, G. K. von Schulthess, T. F. Lüscher, P. A. Kaufmann, A. Buck 18F-cholin images murine atherosclerotic plaques ex vivo. Arterioscler. Thromb. Vasc. Biol., 26, 584-589 (2006)

• A. Bettio, M. Honer, C. Mueller, M. Bruehlmeier, U. Mueller, R. Schibli, V. Groehn, P. A. Schubiger, S. M. Ametamey ”Synthesis and preclinical evaluation of the first 18F-labelled folic acid derivative for the PET imaging of folate receptor positive tumors” J. Nucl. Med. 47, 1153-1160 (2006).

• M. Honer, B. Hengerer, M. Blagoev, S. Hintermann, P. Waldmeier, P. A. Schubiger, S. M. Ametamey “Comparison of [18F]FDOPA, [18F]FMT, and [18F]FECNT for imaging dopaminergic neurotransmission in mice” Nucl. Med. Biology 33, 607-614 (2006).
  
  
• Mindt T. L.; Struthers H.; Brans L.; Anguelov T.; Schweinsberg C.; Maes V.; Tourwe D.; Schibli R.* (2006) "Click to Chelate": Synthesis and Installation of Metal Chelates into Biomolecules in a Single Step. J. Am. Chem. Soc. 128, 15096.

  2. Müller C., Brühlmeier M., Schubiger P.A., Schibli R.* (2006) Effects of Antifolate Drugs on the Cellular Uptake of Radiofolates In Vitro and In Vivo. J. Nucl. Med., 47, 2057.
  
  

• Müller C., Hohn A., Schubiger P.A., Schibli R.* (2006) Preclinical evaluation of novel organometallic ^99mTc-folate and ^99mTc-pteroate radiotracers for folate receptor-positive tumor targeting. Eur. J. Nucl. Med. 33, 1007.
  
  
• Müller C., Schubiger P.A., Schibli R.* (2006) In vitro and in vivo targeting of different folate receptor-positive cancer cell lines with a novel ^99mTc-radiofolate tracer. Eur. J. Nucl. Med. 33, 11620.
  
  
• 5. Bettio A.; Honer M., Müller C., Brühlmeier M., Müller U., Schibli R. Groehn V. Schubiger P.A., Ametamey S.M.* (2006) Synthesis and Preclinical Evaluation of a ¹⁸F-Labelled Folic Acid Derivative for PET Imaging of Folate Receptor-Positive Tumors. J. Nucl. Med., 47, 1153.
  
  
• Müller C., Schubiger P.A., Schibli R.* (2006) Synthesis and in Vitro/in Vivo Evaluation of Novel ^99mTc(CO)₃-Folates. Bioconjugate Chem., 17, 797.
  
  
• Kim Y.-S., Hea Z., Schibli R., Liu S.* (2006) Synthesis, characterization and X-ray crystal structure of [Re(L4)(CO)₃]Br · 2CH₃OH (L4=N,N-bis[(2-diphenylphosphino)ethyl]-methoxyethylamine): A model compound for novel cationic ^99mTc(I)-tricarbonyl radiotracers useful for heart imaging. Inorg. Chim. Acta, 359, 2479.
  
  
• Lehaire M.-L., Grundler P.V., Steinhauser S., Marti N., Helm L., Hegetschweiler K., Schibli R.*, Merbach, A.E.* (2006): Water-Exchange Study Revealed Unexpected Substitution Behavior of [(CO)₂(NO)Re(H₂O)₃]²⁺ in Aqueous Media. Inorg. Chem., 45, 4199.

2005

• M. Bruehlmeier, B. Kaser-Hotz, R. Ackermann, C. R. Bley, M. Wergin, P. A. Schubiger, S. M. Ametamey “Measurement of tumor hypoxia in spontaneous canine sarcomas ” Veterinary Radiology and Ultrasound 46(4), 348-354 (2005).

• J. Gruenberg, I. Novak-Hofer, M. Honer, K. Zimmermann, K. Knogler, P. Blaeuenstein, S. Ametamey, H. R. Maecke, P. A. Schubiger “In vivo evaluation of 177Lu and 67/64Cu-labeled recombinant fragments of antibody chCE7 for radioimmunotherapy and PET imaging of L1-CAM positive tumors” Clin. Cancer Res 11(14) (2005).

• K. Allemann, M. T. Wyss, M. Wergin, S. Ohlerth, C. R. Bley, S. M. Evans, P. A. Schubiger, S. M. Ametamey, B. Kaser Hotz “Measurements of hypoxia and perfusion in feline vaccine associated sarcomas (VAS) using [18F]-FMISO/[18F]-EF5 and positron emission tomography (PET)” Veterinary Radiology Ultrasound 3, 211-221 (2005).
• Schibli R.^*, Marti N., Maurer P., Spingler B., Lehaire M-L., Gramlich V., Barnes C.L. (2005) Syntheses, Spectroscopic and Structural Characterization of Monomeric and Dimeric Dicarbonyl-Nitrosyl Complexes of Technetium(I) and Rhenium(I) in Aqueous Media. Inorg. Chem., 44, 683.
• Dumas C, Petrig J., Frei L., Spingler B., Schibli R.^* (2005) Functionalization of Glucose at Position C-3 for Transition Metal Coordination: Organo-Rhenium Complexes with Carbohydrate Skeletons. Bioconjugate Chem., 16, 421.
  
  
• Schibli R.^*, Dumas C., Petrig J., Spadola L., Scapozza L., Garcia-Garayoa E., Schubiger P.A. (2005) Synthesis and in Vitro Characterization of Organometallic Rhenium and Technetium Glucose Complexes against Glut 1 and Hexokinase. Bioconjugate Chem., 16, 105
  
  
• Marti N., Spingler B., Breher F., Schibli R.* (2005) Comparative Studies of Substitution Reactions of Rhenium(I) Dicarbonyl-Nitrosyl and Tricarbonyl Complexes in Aqueous Media. Inorg. Chem., 44; 6082
  
  
• The glucose project was initiated by Schubiger/Alberto in 1998. However, data published on this subject are entirely generated under the supervision of Schibli.