“Drug development” and new fluorine-18 labeling strategies in collaboration with pharmaceutical industry

• M. Honer, T. Ebenhan, S. M. Ametamey, P. A. Schubiger, M. Becquet, S. Ferretti, C. Cannet, M. Rausch and P. M. J. McSheehy “Comparison of [18F]-tracers in various experimental tumour models by PET imaging and identification of an early response biomarker for the novel microtubule stabiliser patupilone” Molecular Imaging & Biology, 11, 308-321 (2009).

• A. Höhne, L. Yu, L. Mu, M. Reiher, U. Voigtmann, U. Klar, K. Graham, P. A. Schubiger, S. M. Ametamey „Organnofluorosilanes as model compounds for 18F-labeled silicon-based PET tracers and their hydrolytic stability-experimental data and theoretical calculations„ Chemistry-A European Journal 15, 3736-3743 (2009).

• U. Roehn, J. Becaud, L. Mu, A. Srinivan, T. Stellfeld, A. Fitzner, K. Graham, L. Ludger, P. A. Schubiger, S. M. Ametamey “Nucleophilic ring-opening of activated aziridines: A one-step method for labelling biomolecules with fluorine-18” J Fluorine Chem. 130, 902-912 (2009).

• J. Becaud, L. Mu, M. Karramkam, P. A. Schubiger, S. M. Ametamey, K. Graham, T. Stellfed, L. Lehmann, S. Borkowski, D. Berndorff, L. Dinkelborg, A. Srinivasan, R. Smits, B. Koksch “Direct one-step fluorine-18 labeling of peptides via nucleophilic aromatic substitution” Bioconjugate Chemistry (in press).

• Höhne, L. Mu, M. Honer, P.A. Schubiger, S. M. Ametamey, K. Graham, T. Stellfeld, S. Borkowski, D. Berndorf, U. Klar, U. Voigmann, J. E. Cyr, M. Friebe, L. Ludger, A. Srinivasan “Synthesis, 18F-labeling, and in vitro and in vivo studies of bombesin peptides modified with silicon-based building blocks” Bioconjugate Chemistry 19, 1871-1879 (2008).

• L. Mu, A. Höhne, P. A. Schubiger, S. M. Ametamey, K. Graham, T. Stellfeld, S. Borkowski, D. Berndorf, U. Klar, U. Voigmann, J. E. Cyr, M. Friebe, L. Ludger, A. Srinivasan Silicon-based building blocks for one-step F-18-radiolabeling of peptides for PET imaging Ang. Chem-Int 47, (26) 4922-4925 (2008).